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Mouse Anti-DNTT Recombinant Antibody (CAP647) (CBMAB-AP1935LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CAP647
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide of human DNTT
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DNA Nucleotidylexotransferase
Introduction
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human1791
Mouse21673
UniProt ID
HumanP04053
MouseP09838
Alternative Names
DNA Nucleotidylexotransferase; Terminal Deoxynucleotidyltransferase; Terminal Addition Enzyme; Terminal Transferase; EC 2.7.7.31; TDT;
Function
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Biological Process
DNA metabolic process Source: UniProtKB
DNA modification Source: UniProtKB-KW
Double-strand break repair via nonhomologous end joining Source: GO_Central
Response to ATP Source: Ensembl
Cellular Location
Nucleus
More Infomation

Klein, F., Roux, J., Cvijetic, G., Rodrigues, P. F., von Muenchow, L., Lubin, R., ... & Tussiwand, R. (2022). Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors. Nature Immunology, 23(4), 505-517.

Acharya, R., Günder, D., Breuer, T., Schmitz, G., Klauk, H., & Witte, G. (2021). Stability of organic thin-film transistors based on ultrathin films of dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT). Journal of Materials Chemistry C, 9(1), 270-280.

Guo, J., Liu, D., Li, W., Yu, B., Tian, H., Zhu, F., & Yan, D. (2021). High-performance 2, 9-DPh-DNTT organic thin-film transistor by weak epitaxy growth method. Organic Electronics, 93, 106170.

Guo, J., Yu, B., Zhu, F., & Yan, D. (2021). Significant improvement of 2, 9-DPh-DNTT organic thin-film transistors based on organic heterojunction buffer layer. Organic Electronics, 93, 106159.

Sugiyama, M., Jancke, S., Uemura, T., Kondo, M., Inoue, Y., Namba, N., ... & Sekitani, T. (2021). Mobility enhancement of DNTT and BTBT derivative organic thin-film transistors by triptycene molecule modification. Organic Electronics, 96, 106219.

Yamaguchi, Y., Kojiguchi, Y., Kawata, S., Mori, T., Okamoto, K., Tsutsui, M., ... & Yasuda, T. (2020). Solution-processable organic semiconductors featuring S-shaped dinaphthothienothiophene (S-DNTT): Effects of alkyl chain length on self-organization and carrier transport properties. Chemistry of Materials, 32(12), 5350-5360.

Kawabata, K., Usui, S., & Takimiya, K. (2019). Synthesis of soluble dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT) derivatives: One-step functionalization of 2-bromo-DNTT. The Journal of Organic Chemistry, 85(1), 195-206.

Za'aba, N. K., Morrison, J. J., & Taylor, D. M. (2017). Effect of relative humidity and temperature on the stability of DNTT transistors: A density of states investigation. Organic Electronics, 45, 174-181.

Breuer, T., Karthäuser, A., Klemm, H., Genuzio, F., Peschel, G., Fuhrich, A., ... & Witte, G. (2017). Exceptional dewetting of organic semiconductor films: the case of dinaphthothienothiophene (DNTT) at dielectric interfaces. ACS Applied Materials & Interfaces, 9(9), 8384-8392.

Wang, X., Zhang, J., Chen, Y., & Chan, P. K. (2017). Molecular dynamics study of thermal transport in a dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT) organic semiconductor. Nanoscale, 9(6), 2262-2271.

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For research use only. Not intended for any clinical use.

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