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Mouse Anti-DNTT Recombinant Antibody (CBYJT-1197) (CBMAB-T0211-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1197
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of human TDT
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
TBS, pH 7.4, 0.5% BSA, 25% Glycerol
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
DNA Nucleotidylexotransferase
Introduction
DNTT is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, DNTT is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments.
Entrez Gene ID
1791
UniProt ID
P04053
Alternative Names
DNA Nucleotidylexotransferase; Terminal Deoxynucleotidyltransferase; Terminal Addition Enzyme; Terminal Transferase; EC 2.7.7.31; TDT
Function
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Biological Process
DNA metabolic process Source: UniProtKB
DNA modification Source: UniProtKB-KW
Double-strand break repair via nonhomologous end joining Source: GO_Central
Response to ATP Source: Ensembl
Cellular Location
Nucleus
More Infomation

Klein, F., Roux, J., Cvijetic, G., Rodrigues, P. F., von Muenchow, L., Lubin, R., ... & Tussiwand, R. (2022). Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors. Nature Immunology, 23(4), 505-517.

Acharya, R., Günder, D., Breuer, T., Schmitz, G., Klauk, H., & Witte, G. (2021). Stability of organic thin-film transistors based on ultrathin films of dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT). Journal of Materials Chemistry C, 9(1), 270-280.

Guo, J., Liu, D., Li, W., Yu, B., Tian, H., Zhu, F., & Yan, D. (2021). High-performance 2, 9-DPh-DNTT organic thin-film transistor by weak epitaxy growth method. Organic Electronics, 93, 106170.

Guo, J., Yu, B., Zhu, F., & Yan, D. (2021). Significant improvement of 2, 9-DPh-DNTT organic thin-film transistors based on organic heterojunction buffer layer. Organic Electronics, 93, 106159.

Sugiyama, M., Jancke, S., Uemura, T., Kondo, M., Inoue, Y., Namba, N., ... & Sekitani, T. (2021). Mobility enhancement of DNTT and BTBT derivative organic thin-film transistors by triptycene molecule modification. Organic Electronics, 96, 106219.

Yamaguchi, Y., Kojiguchi, Y., Kawata, S., Mori, T., Okamoto, K., Tsutsui, M., ... & Yasuda, T. (2020). Solution-processable organic semiconductors featuring S-shaped dinaphthothienothiophene (S-DNTT): Effects of alkyl chain length on self-organization and carrier transport properties. Chemistry of Materials, 32(12), 5350-5360.

Kawabata, K., Usui, S., & Takimiya, K. (2019). Synthesis of soluble dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT) derivatives: One-step functionalization of 2-bromo-DNTT. The Journal of Organic Chemistry, 85(1), 195-206.

Za'aba, N. K., Morrison, J. J., & Taylor, D. M. (2017). Effect of relative humidity and temperature on the stability of DNTT transistors: A density of states investigation. Organic Electronics, 45, 174-181.

Breuer, T., Karthäuser, A., Klemm, H., Genuzio, F., Peschel, G., Fuhrich, A., ... & Witte, G. (2017). Exceptional dewetting of organic semiconductor films: the case of dinaphthothienothiophene (DNTT) at dielectric interfaces. ACS Applied Materials & Interfaces, 9(9), 8384-8392.

Wang, X., Zhang, J., Chen, Y., & Chan, P. K. (2017). Molecular dynamics study of thermal transport in a dinaphtho [2, 3-b: 2′, 3′-f] thieno [3, 2-b] thiophene (DNTT) organic semiconductor. Nanoscale, 9(6), 2262-2271.

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For research use only. Not intended for any clinical use.

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