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Mouse Anti-DLG2 Recombinant Antibody (CBYCD-298) (CBMAB-D1030-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-298
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Membrane Protein, Palmitoylated 2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Discs Large MAGUK Scaffold Protein 2
Introduction
DLG2 belongs to the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Additional transcript variants have been described, but their full-length nature is not known.
Entrez Gene ID
1740
UniProt ID
Q15700
Alternative Names
Discs Large MAGUK Scaffold Protein 2; Protein Phosphatase 1, Regulatory Subunit 58; Channel-Associated Protein Of Synapse-110; Postsynaptic Density Protein PSD-93; Chapsyn-110; Discs, Large Homolog 2, Chapsyn-110 (Drosophila); Channel-Associated Protein Of Synapses, 110kDa; Discs, Large Homolog 2 (Drosophila);
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Biological Process
Anterograde axonal protein transport Source: ARUK-UCL
Cell-cell adhesion Source: GO_Central
Cellular response to potassium ion Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Retrograde axonal protein transport Source: ARUK-UCL
Cellular Location
Cell membrane; Postsynaptic density; Synapse; Membrane; Axon; Perikaryon. Concentrated in soma and postsynaptic density of a subset of neurons.
PTM
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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