Mouse Anti-DLG2 Recombinant Antibody (4C3) (CBMAB-0498-CN)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4C3

Antibody Isotype

IgG1

Application

ELISA, MA

Basic Information

Immunogen

Recombinant protein of DLG2 (aa. 143-277)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Discs Large MAGUK Scaffold Protein 2

Introduction

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Entrez Gene ID

1740

UniProt ID

Q15700

Alternative Names

Discs, Large Homolog 2 (Drosophila); Channel-Associated Protein Of Synapse-110; Postsynaptic Density Protein PSD-93; Chapsyn-110; Discs, Large Homolog 2, Chapsyn-110 (Drosophila); Channel-Associated Protein Of Synapses, 110kDa; Protein Phosphatase 1, Regulatory Subunit 58; Discs, Large Homolog 2, Chapsyn-110; Protein Phosphatase 1; Regulatory Subunit 58; Discs Large 2; PPP1R58; PSD-93; PSD93

Function

Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Biological Process

Anterograde axonal protein transport Source: ARUK-UCL
Cell-cell adhesion Source: GO_Central
Cellular response to potassium ion Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Retrograde axonal protein transport Source: ARUK-UCL

Cellular Location

Cell membrane; Postsynaptic density; Synapse; Membrane; Axon; Perikaryon. Concentrated in soma and postsynaptic density of a subset of neurons.

PTM

Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.

More Infomation

References

Pass, R., Haan, N., Humby, T., Wilkinson, L. S., Hall, J., & Thomas, K. L. (2022). Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior, 21(4), e12799.

Yoo, T., Kim, S. G., Yang, S. H., Kim, H., Kim, E., & Kim, S. Y. (2020). A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum. Molecular Autism, 11(1), 1-14.

Shao, Y. W., Wood, G. A., Lu, J., Tang, Q. L., Liu, J., Molyneux, S., ... & Khokha, R. (2019). Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene, 38(2), 291-298.

Wu, H. C., Chen, C. M., Chen, Y. C., Fung, H. C., Chang, K. H., & Wu, Y. R. (2018). DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging, 64, 158-e1.

Ali, S., Hoven, A., Dress, R. J., Schaal, H., Alferink, J., & Scheu, S. (2018). Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells. BMC genomics, 19(1), 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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