Mouse Anti-DIP2A Monoclonal Antibody (4E6) (CBMAB-1013-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4E6

Antibody Isotype

IgG2a

Application

ELISA, WB

Basic Information

Immunogen

Partial recombinant protein DIP2A (NP_055966, aa 107-301) with GST tag

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

Located in aa 107-301, partial

Target

Full Name

DIP2 disco-interacting protein 2 homolog A (Drosophila)

Introduction

DIP2A is not highly expressed. DIP2A may be involved in axon patterning in the central nervous system.

Entrez Gene ID

23181

UniProt ID

Q14689

Alternative Names

DIP2; C21orf106

Function

Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity).

Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity).

Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002).

Biological Process

Acetyl-CoA biosynthetic process Source: UniProtKB
Dendritic spine morphogenesis Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Positive regulation of peptidyl-lysine acetylation Source: UniProtKB

Cellular Location

Cell membrane; Mitochondrion; Dendritic spine

More Infomation

References

Xi, Y., Hao, M., Liang, Q., Li, Y., Gong, D. W., & Tian, Z. (2021). Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A–Smad2/3 in rats following myocardial infarction. Journal of Sport and Health Science, 10(5), 594-603.

Kinatukara, P., Subramaniyan, P. S., Patil, G. S., Shambhavi, S., Singh, S., Mhetre, A., ... & Sankaranarayanan, R. (2020). Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition. Transgenic Research, 29(5), 553-562.

Li, Y., Qiu, S., Zhong, W., Shi, J., Cui, H., Li, Y., ... & Liu, Y. (2020). rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder. Research in Autism Spectrum Disorders, 70, 101475.

Sah, R. K., Yang, A., Bah, F. B., Adlat, S., Bohio, A. A., Oo, Z. M., ... & Zheng, Y. (2019). Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. PloS one, 14(7), e0213702.

Ma, J., Zhang, L. Q., He, Z. X., He, X. X., Wang, Y. J., Jian, Y. L., ... & Zhu, X. J. (2019). Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin. PLoS biology, 17(10), e3000461.

Nie, E., Miao, F., Jin, X., Wu, W., Zhou, X., Zeng, A., ... & You, Y. (2019). Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. Oncogene, 38(15), 2706-2721.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-DIP2A Antibody (1B10)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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