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Mouse Anti-DDX41 Antibody (1A10) (CBMAB-0283-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A10
Antibody Isotype
IgG1
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DDX41
Introduction
DDX41 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 41) is putative RNA helicase, which characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). DDX41 plays a role in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Entrez Gene ID
51428
UniProt ID
Q9UJV9
Alternative Names
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41; DEAD Box Protein Abstrakt Homolog; DEAD Box Protein 41; ABS; DEAD-Box Protein Abstrakt; Putative RNA Helicase; 2900024F02Rik; EC 3.6.4.13; EC 3.6.1
Function
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.
Biological Process
Apoptotic process Source: ProtInc
Cell differentiation Source: UniProtKB
Cell population proliferation Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
Positive regulation of type I interferon production Source: Reactome
Cellular Location
Nucleus
Involvement in disease
Myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF):
A familial cancer predisposition syndrome with incomplete penetrance, characterized by increased susceptibility to myeloid neoplasms and rarely to lymphoid malignancies. MPLPF inheritance is autosomal dominant.
More Infomation

Weinreb, J. T., Gupta, V., Sharvit, E., Weil, R., & Bowman, T. V. (2022). Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish. Haematologica, 107(3), 644.

Shin, W. Y., Yoon, S. Y., Park, R., Kim, J. A., Song, H. H., Bang, H. I., ... & Kim, J. (2022). A novel bi-alleleic DDX41 mutations in B-cell lymphoblastic leukemia: case report. BMC medical genomics, 15(1), 1-7.

Qin, K., Jian, D., Xue, Y., Cheng, Y., Zhang, P., Wei, Y., ... & Yuan, X. (2021). DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response. Oncology reports, 45(3), 1213-1225.

Zhang, Y., Wang, F., Chen, X., Liu, H., Wang, X., Chen, J., ... & Liu, H. (2021). Next‐generation sequencing reveals the presence of DDX41 mutations in acute lymphoblastic leukemia and aplastic anemia. EJHaem, 2(3), 508-513.

Gan, Z., Cheng, J., Hou, J., Xia, H., Chen, W., Xia, L., ... & Lu, Y. (2020). Molecular and functional characterization of tilapia DDX41 in IFN regulation. Fish & Shellfish Immunology, 99, 386-391.

Venugopal, P., Cheah, J. J., Eshraghi, L., Shahrin, N. H., Homan, C., Feng, J., ... & Scott, H. S. (2019). An integrative genomic approach to examine mutations and biological pathways associated with hematological malignancy development in DDX41 mutated families. Blood, 134, 2686.

Stavrou, S., Aguilera, A. N., Blouch, K., & Ross, S. R. (2018). DDX41 recognizes RNA/DNA retroviral reverse transcripts and is critical for in vivo control of murine leukemia virus infection. MBio, 9(3), e00923-18.

Ma, J. X., Li, J. Y., Fan, D. D., Feng, W., Lin, A. F., Xiang, L. X., & Shao, J. Z. (2018). Identification of DEAD-box RNA helicase DDX41 as a trafficking protein that involves in multiple innate immune signaling pathways in a zebrafish model. Frontiers in immunology, 9, 1327.

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For research use only. Not intended for any clinical use.

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