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Rabbit Anti-DDX41 Recombinant Antibody (D3F1Z) (CBMAB-CP0450-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D3F1Z
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala98 of human DDX41 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DDX41
Introduction
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
Entrez Gene ID
Human51428
Mouse72935
Rat314336
UniProt ID
HumanQ9UJV9
MouseQ91VN6
RatB2RYL8
Alternative Names
DEAD-Box Helicase 41; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41; DEAD Box Protein Abstrakt Homolog; DEAD Box Protein 41; ABS; Probable ATP-Dependent RNA Helicase DDX41;
Function
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.
Biological Process
Apoptotic process Source: ProtInc
Cell differentiation Source: UniProtKB
Cell population proliferation Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
Positive regulation of type I interferon production Source: Reactome
Cellular Location
Nucleus
Involvement in disease
Myeloproliferative/lymphoproliferative neoplasms, familial (MPLPF):
A familial cancer predisposition syndrome with incomplete penetrance, characterized by increased susceptibility to myeloid neoplasms and rarely to lymphoid malignancies. MPLPF inheritance is autosomal dominant.
More Infomation

Weinreb, J. T., Gupta, V., Sharvit, E., Weil, R., & Bowman, T. V. (2022). Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish. Haematologica, 107(3), 644.

Shin, W. Y., Yoon, S. Y., Park, R., Kim, J. A., Song, H. H., Bang, H. I., ... & Kim, J. (2022). A novel bi-alleleic DDX41 mutations in B-cell lymphoblastic leukemia: case report. BMC medical genomics, 15(1), 1-7.

Qin, K., Jian, D., Xue, Y., Cheng, Y., Zhang, P., Wei, Y., ... & Yuan, X. (2021). DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response. Oncology reports, 45(3), 1213-1225.

Zhang, Y., Wang, F., Chen, X., Liu, H., Wang, X., Chen, J., ... & Liu, H. (2021). Next‐generation sequencing reveals the presence of DDX41 mutations in acute lymphoblastic leukemia and aplastic anemia. EJHaem, 2(3), 508-513.

Gan, Z., Cheng, J., Hou, J., Xia, H., Chen, W., Xia, L., ... & Lu, Y. (2020). Molecular and functional characterization of tilapia DDX41 in IFN regulation. Fish & Shellfish Immunology, 99, 386-391.

Venugopal, P., Cheah, J. J., Eshraghi, L., Shahrin, N. H., Homan, C., Feng, J., ... & Scott, H. S. (2019). An integrative genomic approach to examine mutations and biological pathways associated with hematological malignancy development in DDX41 mutated families. Blood, 134, 2686.

Stavrou, S., Aguilera, A. N., Blouch, K., & Ross, S. R. (2018). DDX41 recognizes RNA/DNA retroviral reverse transcripts and is critical for in vivo control of murine leukemia virus infection. MBio, 9(3), e00923-18.

Ma, J. X., Li, J. Y., Fan, D. D., Feng, W., Lin, A. F., Xiang, L. X., & Shao, J. Z. (2018). Identification of DEAD-box RNA helicase DDX41 as a trafficking protein that involves in multiple innate immune signaling pathways in a zebrafish model. Frontiers in immunology, 9, 1327.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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