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Mouse Anti-CYCS Recombinant Antibody (C1) (CBMAB-AP1813LY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
C1
Antibody Isotype
IgG2a, κ
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
RPA594Hu01-Recombinant Cytochrome C, Somatic (CYCS)
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome C, Somatic
Introduction
CYCS (Cytochrome C, Somatic) is a Protein Coding gene. Diseases associated with CYCS include Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.
Entrez Gene ID
Human54205
Rat25309
UniProt ID
HumanP99999
RatP62898
Alternative Names
Cytochrome C, Somatic; CYC; Cytochrome C; THC4; HCS;
Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
Apoptotic process Source: UniProtKB-KW
Cellular respiration Source: UniProtKB
Cellular response to oxidative stress Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
Mitochondrion organization Source: Reactome
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Cellular Location
Mitochondrion intermembrane space. Loosely associated with the inner membrane.
Involvement in disease
Thrombocytopenia 4 (THC4):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
PTM
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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