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CYCS

CYCS (Cytochrome C, Somatic) is a Protein Coding gene. Diseases associated with CYCS include Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.
Full Name
Cytochrome C, Somatic
Alternative Names
Cytochrome C, Somatic; CYC; Cytochrome C; THC4; HCS;
Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
Apoptotic process Source: UniProtKB-KW
Cellular respiration Source: UniProtKB
Cellular response to oxidative stress Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
Mitochondrion organization Source: Reactome
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Cellular Location
Mitochondrion intermembrane space. Loosely associated with the inner membrane.
Involvement in disease
Thrombocytopenia 4 (THC4):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
PTM
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

Anti-CYCS antibodies

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: C1
Application*: ICC, IHC, IP, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Horse, Human, Mouse, Rat
Clone: 2C12
Application*: FC, IF, IHC, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 470
Application*: ELISA, IF, IHC, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 8G3
Application*: IF, IHC, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP605
Application*: FC, IF, IHC, IP, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP604
Application*: ELISA, IHC, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CF129
Application*: ELISA, WB, IHC
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB255A
Application*: ELISA, WB, IHC
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB179
Application*: WB, IHC
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Application*: FC
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 15F10
Application*: FC, IHC, ICC, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Horse, Human, Mouse, Rat, Goat, Sheep
Clone: SJL2apo
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Horse
Clone: SJL2-4
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Pigeon, Mouse, Rat, Horse, Human, Fruit fly
Clone: 7H8.2C12
Application*: P, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG, κ
Specificity: Pigeon
Clone: 2D17
Application*: IH, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: RAC28-37AB11
Application*: IC, IF, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Horse
Clone: CTC03
Application*: E, FC, IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: 10B2633
Application*: E, FC
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3512
Application*: WB
Target: CYCS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-3511
Application*: IC, IH, IP, WB
Target: CYCS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2102
Application*: WB, IP, P, IC
Target: CYCS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Pig
Clone: CBWJC-2101
Application*: WB, P
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Horse
Clone: CBWJC-2100
Application*: E, F, IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Dog, Fruit fly, Horse
Clone: CTC05
Application*: P
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXC-2736
Application*: E, WB, IH, IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXC-0635
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Horse
Clone: C-7
Application*: WB, IH
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Horse
Clone: CBXC-1076
Application*: IH, IP, IC
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B2D6
Application*: WB, IP
Target: CYCS
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-0913
Application*: F
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Dog, Fruit fly, Horse
Clone: SPM389
Application*: WB, F, P, IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Pig, Dog, Fruit fly, Horse, Rabbit
Clone: CBXC-3067
Application*: WB, F, IH, IF, P
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-2298
Application*: F, IS
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse, Human
Clone: CBYY-C2386
Application*: E, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C2385
Application*: WB, P, IF, IP, F
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2384
Application*: WB, IH
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2383
Application*: WB, IH, IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1b, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C2381
Application*: E, IF, IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYY-C0531
Application*: IF, P
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYC-2558
Application*: IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-2556
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse, Human
Clone: 7C24
Application*: E, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 6H2
Application*: F, IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 6G1
Application*: WB, P, IF/IC, P, F
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 6B10
Application*: P, IF(P)
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C7
Application*: WB, IH
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human, Mouse
Clone: 3G119
Application*: E, IF, IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: 2G8
Application*: E, F
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F2
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Horse
Clone: 2E9C2
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2D8D11
Application*: E, WB, IH, IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2CYZ-702
Application*: IP, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2CYTC-199
Application*: WB, IP, E, P, AP, F, IC/IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Horse
Clone: 2B5.F8
Application*: IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 14G6
Application*: WB
Target: CYCS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: 136F3
Application*: WB, P
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Horse, Human
Clone: 0.T.26
Application*: C, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Dog, Human
Clone: 3F144
Application*: E, F, IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 37BA11
Application*: WB, F, IC/IF, E
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B5
Application*: E, F, IP, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2.7D5
Application*: IP
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC134
Application*: WB, P, IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Chicken
Clone: EG881
Application*: WB, IHC-p, IF
Target: CYCS
Host: Mouse
Antibody Isotype: IgA
Specificity: Human, Mouse, Rat
Clone: GT577
Application*: P, WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GT1711
Application*: WB
Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4B10
Application*: P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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