CYCS

CYCS (Cytochrome C, Somatic) is a Protein Coding gene. Diseases associated with CYCS include Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity.
Full Name
Cytochrome C, Somatic
Alternative Names
Cytochrome C, Somatic; CYC; Cytochrome C; THC4; HCS;
Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
Apoptotic process Source: UniProtKB-KW
Cellular respiration Source: UniProtKB
Cellular response to oxidative stress Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
Mitochondrion organization Source: Reactome
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Cellular Location
Mitochondrion intermembrane space. Loosely associated with the inner membrane.
Involvement in disease
Thrombocytopenia 4 (THC4):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
PTM
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
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Anti-CYCS antibodies

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Rabbit Anti-CYCS Recombinant Antibody (CBWJC-2102) (CBMAB-C2800WJ)

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Target: CYCS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2102
Application*: WB, P, IF, IP
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBXC-2298) (CBMAB-C0324-CQ)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse
Clone: CBXC-2298
Application*: WB, IP, IF, E, F, P
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBYY-C2386) (CBMAB-C3824-YY)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Horse, Chicken
Clone: CBYY-C2386
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBFYC-2558) (CBMAB-C2632-FY)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-2558
Application*: WB, IH
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBT28) (V2LY-0625-LY3855)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Chicken
Clone: CBT28
Application*: WB, IF, IC, P
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBT4498) (V2LY-0625-LY1304)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4498
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBT3532) (V2LY-0625-LY1303)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3532
Application*: IH, F
Datasheet SDS

Rabbit Anti-CYCS Recombinant Antibody (CBWJC-2101) (V2LY-0125-LY872)

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Target: CYCS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Dog, Fruit fly, Horse, Pigeon
Clone: CBWJC-2101
Application*: WB, P, IF, F
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBXC-3067) (V2LY-0125-LY871)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Horse
Clone: CBXC-3067
Application*: E
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBYY-C2385) (V2LY-0125-LY868)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2385
Application*: WB
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBYY-C2384) (V2LY-0125-LY867)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C2384
Application*: WB, IP, IF, E, F
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBYY-C2383) (V2LY-0125-LY866)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgA
Specificity: Human, Mouse, Rat
Clone: CBYY-C2383
Application*: WB, P
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBYY-C2381) (V2LY-0125-LY865)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C2381
Application*: F, IF, WB, IH
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (CBFYC-2556) (V2LY-0125-LY862)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Chicken
Clone: CBFYC-2556
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-CYCS Recombinant Antibody (EC134) (V2LY-0624-LY134)

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Target: CYCS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC134
Application*: WB, P, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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