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Mouse Anti-CTSH Recombinant Antibody (CBWJC-3424) (CBMAB-C4647WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3424
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Cathepsin H, Accession / GI number: NP_004381
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cathepsin H
Introduction
CTSH (Cathepsin H) is a Protein Coding gene. Diseases associated with CTSH include Thyroid Crisis and Intermittent Explosive Disorder. Among its related pathways are Innate Immune System and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include protein complex binding and peptidase activity. An important paralog of this gene is CTSK.
Entrez Gene ID
1512
UniProt ID
P09668
Alternative Names
Cathepsin H; CPSB; N-Benzoylarginine-Beta-Naphthylamide Hydrolase; Pro-Cathepsin H; Cathepsin B3; Cathepsin BA; EC 3.4.22.16;
Function
Important for the overall degradation of proteins in lysosomes.
Biological Process
Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Bradykinin catabolic process Source: UniProtKB
Cellular protein metabolic process Source: Reactome
Cellular response to thyroid hormone stimulus Source: UniProtKB
Dichotomous subdivision of terminal units involved in lung branching Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
Immune response-regulating signaling pathway Source: UniProtKB
Membrane protein proteolysis Source: UniProtKB
Metanephros development Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neuropeptide catabolic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of peptidase activity Source: UniProtKB
Protein destabilization Source: UniProtKB
Proteolysis Source: UniProtKB
Proteolysis involved in cellular protein catabolic process Source: GO_Central
Response to retinoic acid Source: UniProtKB
Surfactant homeostasis Source: UniProtKB
T cell mediated cytotoxicity Source: UniProtKB
Zymogen activation Source: UniProtKB
Cellular Location
Lysosome
More Infomation

Peng, P., Chen, J. Y., Zheng, K., Hu, C. H., & Han, Y. T. (2021). Favorable Prognostic Impact of Cathepsin H (CTSH) High Expression in Thyroid Carcinoma. International Journal of General Medicine, 14, 5287.

Ye, J., Stefan-Lifshitz, M., & Tomer, Y. (2021). Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation. Journal of Biological Chemistry, 296.

Fløyel, T., Mirza, A. H., Kaur, S., Frørup, C., Yarani, R., Størling, J., & Pociot, F. (2020). The Rac2 GTPase contributes to cathepsin H-mediated protection against cytokine-induced apoptosis in insulin-secreting cells. Molecular and Cellular Endocrinology, 518, 110993.

Oda, K., Luo, Y., Yoshihara, A., Ishido, Y., Sekihata, K., Usukura, K., ... & Suzuki, K. (2017). Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes. Biochemical and biophysical research communications, 483(1), 541-546.

Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., ... & O'Shaughnessy, R. F. (2017). A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology, 139(4), 1228-1241.

Yang, Z., Liu, Y., Qin, L., Wu, P., Xia, Z., Luo, M., ... & Han, Y. P. (2017). Cathepsin H–mediated degradation of HDAC4 for matrix metalloproteinase expression in hepatic stellate cells: implications of epigenetic suppression of matrix metalloproteinases in fibrosis through stabilization of class IIa histone deacetylases. The American journal of pathology, 187(4), 781-797.

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For research use only. Not intended for any clinical use.

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