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Mouse Anti-CSNK1G1 Monoclonal Antibody (1C5) (CBMAB-0975-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C5
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 163-422 of human CSNK1G1 (NP_071331) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Casein Kinase 1 Gamma 1
Introduction
Casein kinase 1 gamma 1 (CSNK1G1) is a member of the casein kinase I gene family, which is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. CSNK1G1 plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin and mutation may be associated with non-syndromic early-onset epilepsy (NSEOE).
Entrez Gene ID
53944
UniProt ID
Q9HCP0
Alternative Names
CK1gamma1
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Phosphorylates CLSPN.
Biological Process
Endocytosis Source: GO_Central
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Wnt signaling pathway Source: GO_Central
Cellular Location
Cytoplasm
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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