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Mouse Anti-CSNK1E Recombinant Antibody (CBWJC-3225) (CBMAB-C4416WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3225
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa153-416 of human CSNK1E (NP_689407) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (PH 7.3), 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CSNK1E
Introduction
CSNK1E (Casein Kinase 1 Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include Advanced Sleep Phase Syndrome. Among its related pathways are Circadian rhythm pathway and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is TPTEP2-CSNK1E.
Entrez Gene ID
1454
UniProt ID
P49674
Alternative Names
Casein Kinase 1 Epsilon; CKI-Epsilon; EC 2.7.11.1; CKIe; Casein Kinase I Isoform Epsilon; Casein Kinase 1, Epsilon; CKIepsilon; EC 2.7.11; HCKIE;
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Ciliary basal body-plasma membrane docking Source: Reactome
Circadian regulation of gene expression Source: UniProtKB
DNA repair Source: ProtInc
Endocytosis Source: GO_Central
G2/M transition of mitotic cell cycle Source: Reactome
Negative regulation of protein binding Source: ParkinsonsUK-UCL
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Positive regulation of non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Protein phosphorylation Source: UniProtKB
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Signal transduction Source: ProtInc
Wnt signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
PTM
Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
More Infomation

Zhou, L., Fitzpatrick, K., Olker, C., Vitaterna, M. H., & Turek, F. W. (2021). Casein kinase 1 epsilon and circadian misalignment impact affective behaviours in mice. European Journal of Neuroscience.

Zhou, L., Fitzpatrick, K., Olker, C., Vitaterna, M. H., & Turek, F. W. (2020). Altered Affective Behaviors in Casein Kinase 1 Epsilon Mutant Mice. bioRxiv.

Guo, G., Wang, K., Hu, S. S., Tian, T., Liu, P., Mori, T., ... & Qin, X. (2019). Autokinase activity of casein kinase 1 δ/ε governs the period of mammalian circadian rhythms. Journal of biological rhythms, 34(5), 482-496.

Lin, S. H., Chen, M. K., Chang, J. H., Velmurugan, B. K., Annamanedi, M., Su, S. C., ... & Yang, S. F. (2019). Impact of polymorphisms in casein kinase 1 epsilon and environmental factors in oral cancer susceptibility. Journal of Cancer, 10(21), 5065.

Lee, K. Y., Ahn, Y. M., Kim, S. H., Kang, H. G., & Joo, E. J. (2018). Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics. Nordic Journal of Psychiatry, 72(8), 599-604.

Bar, I., Merhi, A., Larbanoix, L., Constant, M., Haussy, S., Laurent, S., ... & Delrée, P. (2018). Silencing of casein kinase 1 delta reduces migration and metastasis of triple negative breast cancer cells. Oncotarget, 9(56), 30821.

Varghese, R. T., Young, S., Pham, L., Liang, Y., Pridham, K. J., Guo, S., ... & Sheng, Z. (2018). Casein kinase 1 epsilon regulates glioblastoma cell survival. Scientific reports, 8(1), 1-13.

Janovska, P., Verner, J., Kohoutek, J., Bryjova, L., Gregorova, M., Dzimkova, M., ... & Bryja, V. (2018). Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia. Blood, The Journal of the American Society of Hematology, 131(11), 1206-1218.

Goldberg, L. R., Kirkpatrick, S. L., Yazdani, N., Luttik, K. P., Lacki, O. A., Keith Babbs, R., ... & Bryant, C. D. (2017). Casein kinase 1‐epsilon deletion increases mu opioid receptor‐dependent behaviors and binge eating 1. Genes, Brain and Behavior, 16(7), 725-738.

Morgenstern, Y., Das Adhikari, U., Ayyash, M., Elyada, E., Tóth, B., Moor, A., ... & Ben‐Neriah, Y. (2017). Casein kinase 1‐epsilon or 1‐delta required for Wnt‐mediated intestinal stem cell maintenance. The EMBO journal, 36(20), 3046-3061.

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For research use only. Not intended for any clinical use.

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