CSNK1E

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

CSNK1E

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

Canonical Wnt signaling pathway Source: WormBase
Ciliary basal body-plasma membrane docking Source: Reactome
Circadian regulation of gene expression Source: UniProtKB
DNA repair Source: ProtInc
Endocytosis Source: GO_Central
G2/M transition of mitotic cell cycle Source: Reactome
Negative regulation of protein binding Source: ParkinsonsUK-UCL
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Positive regulation of non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Protein phosphorylation Source: UniProtKB
Regulation of cellular protein localization Source: ParkinsonsUK-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Signal transduction Source: ProtInc
Wnt signaling pathway Source: GO_Central

Cytoplasm; Nucleus

Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.