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Mouse Anti-CRYM Recombinant Antibody (CBFYM-1026) (CBMAB-M1178-FY)


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Published Data
CBMAB-M1178-FY-1
Mouse Anti-CRYM Recombinant Antibody (CBFYM-1026) (CBMAB-M1178-FY) in WB
Western blot and its quantitative results of enzymes in the liver of Sed and Exe mice at age of 15 months. n = 4 per group. ...View More
Zhang, N., Wang, X., Feng, M., Li, M., Wang, J., Yang, H., ... & Gao, F. (2024). Early-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice. Nature Communications, 15(1), 3103.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-M1178-FY-2
Mouse Anti-CRYM Recombinant Antibody (CBFYM-1026) (CBMAB-M1178-FY) in IHC
Striatal expression of µ-crystallin in mice injected with control sgRNA-GFP or Crym KO sgRNA-Crym AAVs. Scale bars, 200 μm. ...View More
Ollivier, M., Soto, J. S., Linker, K. E., Moye, S. L., Jami-Alahmadi, Y., Jones, A. E., ... & Khakh, B. S. (2024). Crym-positive striatal astrocytes gate perseverative behaviour. Nature, 627(8003), 358-366.
Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-M1178-FY-3
Mouse Anti-CRYM Recombinant Antibody (CBFYM-1026) (CBMAB-M1178-FY) in IHC
Crym mRNA expression along with S100β IHC; inset higher magnification (representative of n = 16 sections from 4 mice). Scale bars, 500 μm (main); 20 μm (inset). CC, corpus callosum. AC, anterior commissure. ...View More
Ollivier, M., Soto, J. S., Linker, K. E., Moye, S. L., Jami-Alahmadi, Y., Jones, A. E., ... & Khakh, B. S. (2024). Crym-positive striatal astrocytes gate perseverative behaviour. Nature, 627(8003), 358-366.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYM-1026
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 45-85 near the N-terminus of human µ-crystallin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
crystallin, mu
Introduction
CRYM is a Protein Coding gene. Diseases associated with CRYM include Deafness, Autosomal Dominant 40 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology annotations related to this gene include protein homodimerization activity and NADP binding.
Entrez Gene ID
Human1428
Monkey697588
Rat117024
UniProt ID
HumanQ14894
MonkeyF7DC75
RatQ9QYU4
Alternative Names
Crystallin Mu; Thiomorpholine-Carboxylate Dehydrogenase; THBP; NADP-Regulated Thyroid-Hormone Binding Protein; NADP-Regulated Thyroid-Hormone-Binding Protein; Ketimine Reductase Mu-Crystallin
Function
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
Biological Process
Lysine catabolic process Source: Reactome
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Thyroid hormone metabolic process Source: GO_Central
Thyroid hormone transport Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Deafness, autosomal dominant, 40 (DFNA40):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

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