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Mouse Anti-CRYM Recombinant Antibody (6B3) (V2LY-1206-LY1333)


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Published Data
V2LY-1206-LY1333-1
Mouse Anti-CRYM Recombinant Antibody (6B3) (V2LY-1206-LY1333) in IHC
Immunohistochemical staining of NIS, CRYM, and THRB. Positive (left) and negative (right) immunohistochemical staining of NIS (A), CRYM (B), and THRB (C). ...View More
Schnoell, J., Kotowski, U., Jank, B. J., Stoiber, S., Gurnhofer, E., Schlederer, M., ... & Kadletz-Wanke, L. (2021). Prognostic relevance of thyroid-hormone-associated proteins in adenoid cystic carcinoma of the head and neck. Journal of Personalized Medicine, 11(12), 1352.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY1333-2
Mouse Anti-CRYM Recombinant Antibody (6B3) (V2LY-1206-LY1333) in IHC
Representative images of immunohistochemical staining of tissue microarrays for CRYM. Positive cytoplasmatic staining (n = 15) on the left side and negative staining (n = 103) on the right side. Low-power field, 40×; high-power field (insets), 200×. ...View More
Jank, B. J., Haas, M., Schnoell, J., Schlederer, M., Heiduschka, G., Kenner, L., & Kadletz-Wanke, L. (2021). µ-Crystallin Is Associated with Disease Outcome in Head and Neck Squamous Cell Carcinoma. Journal of Personalized Medicine, 11(12), 1330.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY1333-3
Mouse Anti-CRYM Recombinant Antibody (6B3) (V2LY-1206-LY1333) in WB
30 μg sample of each extract were separated by electrophoresis, transferred to a Western blot, and the indicated proteins immunodetected. This image was used in Vanderplanck et al. (2011) for FSHD, healthy, and DUX4-overexpressing myoblasts. We only added the lane corresponding to DUX4c-overexpressing myoblasts. ...View More
Vanderplanck, C., Tassin, A., Ansseau, E., Charron, S., Wauters, A., Lancelot, C., ... & Coppée, F. (2018). Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei. Skeletal muscle, 8, 1-16.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
V2LY-1206-LY1333-4
Mouse Anti-CRYM Recombinant Antibody (6B3) (V2LY-1206-LY1333) in WB
DUX4 protein overexpression induces different FSHD markers.
24 hours after seeding FSHD and control primary myoblasts were transfected with the indicated expression vectors. Total protein extracts were prepared 48 hours after transfection, 30 µg were separated by electrophoresis (12% PAGE-SDS), transferred to a Western blot and immunodetected with the indicated primary antibodies, appropriate secondary antibodies coupled to HRP and the Lumilight kit (Roche). Actin was stained by Ponceau red on the same membrane before immunodetection and was used as the loading control. A densitometry of the immunoreactive bands was performed. Data are normalized to actin levels in each sample. ...View More
Vanderplanck, C., Ansseau, E., Charron, S., Stricwant, N., Tassin, A., Laoudj-Chenivesse, D., ... & Belayew, A. (2011). The FSHD atrophic myotube phenotype is caused by DUX4 expression. PloS one, 6(10), e26820.
Distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Summary

Host Animal
Mouse
Specificity
Human
Clone
6B3
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB, IP

Basic Information

Immunogen
CRYM (aa215-314) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
crystallin, mu
Entrez Gene ID
1428
UniProt ID
Q14894
Function
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
Biological Process
Lysine catabolic process Source: Reactome
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Sensory perception of sound Source: UniProtKB
Thyroid hormone metabolic process Source: GO_Central
Thyroid hormone transport Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Deafness, autosomal dominant, 40 (DFNA40):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

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