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Rabbit Anti-CRYBA1 Recombinant Antibody (BA0376) (CBMAB-0251CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0376
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from residues in Human beta Crystallin A3
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Crystallin Beta A1
Introduction
The CRYBA1 gene encodes both the beta-A3- and beta-A1-crystallins. Beta-crystallins consist of similar N-terminal and C-terminal domains separated by a short connecting peptide. Each domain folds into 2 similar 'Greek key' motifs, with distinctive beta-sheet folding. Different beta-crystallin proteins can interact with each other to form oligomers of different sizes ranging from dimers to octamers and can also interact with other lens proteins. The protein-protein interactions are predicted to be key in maintaining the transparency of the lens. Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.
Entrez Gene ID
Human1411
Mouse12957
Rat25583
UniProt ID
HumanP05813
MouseP02525
RatP14881
Alternative Names
Crystallin, Beta A1; Eye Lens Structural Protein; CRYB1; Beta Crystallin A3 Chain Transcript LAM; Beta Crystallin A3 Chain Transcript CN; Beta Crystallin A3 Chain Transcript PS; Beta Crystallin A3 Chain Transcript TC; Truncated Beta-Crystallin A3; Crystallin Beta A3/A1; Crystallin, Beta A3; Crystallin Beta A3; CTRCT10
Function
Crystallins are the dominant structural components of the vertebrate eye lens.
Biological Process
Lens development in camera-type eye Source: GO_Central
Negative regulation of cytokine production Source: Ensembl
Negative regulation of ERK1 and ERK2 cascade Source: Ensembl
Negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
Negative regulation of protein kinase B signaling Source: Ensembl
Negative regulation of TOR signaling Source: Ensembl
Positive regulation of anoikis Source: Ensembl
Visual perception Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Cataract 10, multiple types (CTRCT10):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT10 includes congenital zonular with sutural opacities, among others. This is a form of zonular cataract with an erect Y-shaped anterior and an inverted Y-shaped posterior sutural opacities. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
PTM
Specific cleavages in the N-terminal arm occur during lens maturation and give rise to several truncated forms. Cleavages do not seem to have adverse effects on solubility.
S-methylation and glutathionylation occur in normal young lenses and do not seem to be detrimental.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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