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Mouse Anti-CRABP2 Recombinant Antibody (5CRA-3B3) (CBMAB-1426-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5CRA-3B3
Antibody Isotype
IgG2a
Application
WB, IF

Basic Information

Immunogen
Recombinant protein corresponding to full length human CRABPII
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cellular Retinoic Acid Binding Protein 2
Introduction
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol.
Entrez Gene ID
1382
UniProt ID
P29373
Alternative Names
RBP6; CRABP-II
Function
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Biological Process
Embryonic forelimb morphogenesis Source: Ensembl
Epidermis development Source: ProtInc
Positive regulation of collateral sprouting Source: Ensembl
Regulation of transcription, DNA-templated Source: ProtInc
Retinoic acid metabolic process Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm; Nucleus; Endoplasmic reticulum. Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
PTM
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
More Infomation

Meng, J. F., Luo, M. J., & Li, H. B. (2021). Correlation between Plasma Cellular Retinoic Acid-Binding Protein 2 and Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer Cells. Critical Reviews™ in Eukaryotic Gene Expression, 31(3).

Enikeev, A. D., Komelkov, A. V., Axelrod, M. E., Galetsky, S. A., Kuzmichev, S. A., & Tchevkina, E. M. (2021). CRABP1 and CRABP2 protein levels correlate with each other but do not correlate with sensitivity of breast cancer cells to retinoic acid. Biochemistry (Moscow), 86(2), 217-229.

Kimmel, B. R., & Mrksich, M. (2021). Development of an Enzyme‐Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One‐Pot Megamolecule Assembly. Chemistry–A European Journal, 27(71), 17843-17848.

Sato, H., Narita, S., Ishida, M., Kashima, S., Yamamoto, R., Koizumi, A., ... & Habuchi, T. (2021). Cellular retinoic acid-binding protein 2 enhances saturated fatty acid-induced prostate cancer progression.

Jiao, X., Liu, R., Huang, J., Lu, L., Li, Z., Xu, L., & Li, E. (2020). Cellular Retinoic-Acid Binding Protein 2 in Solid Tumor. Current Protein and Peptide Science, 21(5), 507-516.

Lixa, C., Clarkson, M. W., Iqbal, A., Moon, T. M., Almeida, F. C., Peti, W., & Pinheiro, A. S. (2019). Retinoic acid binding leads to CRABP2 rigidification and dimerization. Biochemistry, 58(41), 4183-4194.

Liu, X., Li, H., Wu, M. L., Wu, J., Sun, Y., Zhang, K. L., & Liu, J. (2019). Resveratrol reverses retinoic acid resistance of anaplastic thyroid cancer cells via demethylating CRABP2 gene. Frontiers in endocrinology, 734.

Mosquera, N., Rodriguez-Trillo, A., Mera-Varela, A., Gonzalez, A., & Conde, C. (2018). Uncovering Cellular retinoic acid-binding protein 2 as a potential target for rheumatoid arthritis synovial hyperplasia. Scientific reports, 8(1), 1-9.

Percicote, A. P., Mardegan, G. L., Gugelmim, E. S., Ioshii, S. O., Kuczynski, A. P., Nagashima, S., & de Noronha, L. (2018). Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas. Diagnostic Pathology, 13(1), 1-7.

Fischer-Huchzermeyer, S., Dombrowski, A., Hagel, C., Mautner, V. F., Schittenhelm, J., & Harder, A. (2017). The cellular retinoic acid binding protein 2 promotes survival of malignant peripheral nerve sheath tumor cells. The American journal of pathology, 187(7), 1623-1632.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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