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Rabbit Anti-CRABP1 Recombinant Antibody (D7F9T) (CBMAB-CP0365-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Cattle
Clone
D7F9T
Antibody Isotype
IgG
Application
WB, IF, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu102 of human CRABP1 protein.
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cellular Retinoic Acid Binding Protein 1
Introduction
CRABP1 (Cellular Retinoic Acid Binding Protein 1) is a Protein Coding gene. Diseases associated with CRABP1 include Teratocarcinoma and Embryonal Carcinoma. Among its related pathways are Vitamin A and Carotenoid Metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is CRABP2.
Entrez Gene ID
Human1381
Mouse12903
Rat25061
Cattle282201
UniProt ID
HumanP29762
MouseP62965
RatP62966
CattleP62964
Alternative Names
Cellular Retinoic Acid Binding Protein 1; Cellular Retinoic Acid-Binding Protein 1; Cellular Retinoic Acid-Binding Protein I; CRABP-I; RBP5; CRABPI; CRABP;
Function
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Biological Process
Multicellular organism development Source: ProtInc
Retinoic acid catabolic process Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm
More Infomation

Lin, Y. W., Nhieu, J., Wei, C. W., Lin, Y. L., Kagechika, H., & Wei, L. N. (2021). Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation. Cell Communication and Signaling, 19(1), 1-11.

Enikeev, A. D., Komelkov, A. V., Axelrod, M. E., Galetsky, S. A., Kuzmichev, S. A., & Tchevkina, E. M. (2021). CRABP1 and CRABP2 protein levels correlate with each other but do not correlate with sensitivity of breast cancer cells to retinoic acid. Biochemistry (Moscow), 86(2), 217-229.

Lin, Y. L., Lin, Y. W., Nhieu, J., Zhang, X., & Wei, L. N. (2020). Sonic hedgehog-gli1 signaling and cellular retinoic acid binding protein 1 gene regulation in motor neuron differentiation and diseases. International journal of molecular sciences, 21(11), 4125.

Lin, Y. W., Park, S. W., Lin, Y. L., Burton, F. H., & Wei, L. N. (2020). Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. International journal of obesity, 44(2), 466-474.

Park, S. W., Nhieu, J., Persaud, S. D., Miller, M. C., Xia, Y., Lin, Y. W., ... & Wei, L. N. (2019). A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1. Scientific reports, 9(1), 1-12.

Nagpal, I., & Wei, L. N. (2019). All-trans retinoic acid as a versatile cytosolic signal modulator mediated by CRABP1. International journal of molecular sciences, 20(15), 3610.

Park, S. W., Nhieu, J., Lin, Y. W., & Wei, L. N. (2019). All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation. European journal of pharmacology, 858, 172485.

Lin, Y. L., Persaud, S. D., Nhieu, J., & Wei, L. N. (2017). Cellular retinoic acid–binding protein 1 modulates stem cell proliferation to affect learning and memory in male mice. Endocrinology, 158(9), 3004-3014.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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