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Mouse Anti-COIL Recombinant Antibody (CBCNC-240) (CBMAB-C2550-CN)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBCNC-240
Antibody Isotype
IgG1
Application
WB, IF, IHC

Basic Information

Immunogen
KLH-conjugated synthetic peptide, FPCRKAKKRAFKLMEDEETC (corresponding to amino acid residues 104-122 of mouse Coilin)
Specificity
Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 50% glycerol, pH 7.2
Concentration
1 mg/mL

Target

Full Name
Coilin
Introduction
COIL (Coilin) is a Protein Coding gene. Diseases associated with COIL include Spinal Muscular Atrophy and Ischemic Neuropathy. Among its related pathways are Translational Control. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding.
Entrez Gene ID
Mouse12812
Rat50998
UniProt ID
MouseQ5SU73
RatE9PTJ1
Alternative Names
Coilin; P80-Coilin; CLN80; Coilin P80; P80;
Function
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
Biological Process
Spliceosomal snRNP assembly Source: GO_Central
Cellular Location
Nucleus; Cajal body
PTM
Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.
Phosphorylation during mitosis is associated with disassembly of CBs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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