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Mouse Anti-CNN1 Recombinant Antibody (CBYY-C0677) (V2LY-1206-LY431)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C0677
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Full-length recombinant CNN1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calponin 1
Entrez Gene ID
1264
UniProt ID
P51911
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
Biological Process
Actomyosin structure organization Source: InterPro
Negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of smooth muscle contraction Source: UniProtKB
Cellular Location
Cytoskeleton; Focal adhesion
More Infomation

Choo, Y. Y., Sakai, T., Komatsu, S., Ikebe, R., Jeffers, A., Singh, K. P., ... & Ikebe, M. (2022). Calponin 1 contributes to myofibroblast differentiation of human pleural mesothelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology.

Mamoor, S. (2021). Differential expression of calponin 1 in cancers of the breast.

Liu, W., Fu, X., & Li, R. (2021). CNN1 regulates the DKK1/Wnt/β‑catenin/c‑myc signaling pathway by activating TIMP2 to inhibit the invasion, migration and EMT of lung squamous cell carcinoma cells. Experimental and therapeutic medicine, 22(2), 1-9.

Wang, Z., Li, T. E., Chen, M., Pan, J. J., & Shen, K. W. (2020). miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathway. Aging (Albany NY), 12(2), 1867.

Feng, H. Z., Wang, H., Takahashi, K., & Jin, J. P. (2019). Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. Journal of molecular and cellular cardiology, 129, 49-57.

Zhao, H., Yang, K., Liu, Q., Hu, J., Wu, W., & Wang, J. (2019). Expression of calponin-1 and its pathogenic role in systemic sclerosis. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 39(3), 279-285.

Cetin, O., Karaman, E., Boza, B., Cim, N., & Sahin, H. G. (2018). Maternal serum calponin 1 level as a biomarker for the short-term prediction of preterm birth in women with threatened preterm labor. The Journal of Maternal-Fetal & Neonatal Medicine, 31(2), 216-222.

Xu, H., Wu, F., Zhang, H., Yang, C., Li, K., Wang, H., ... & Dai, Z. (2017). Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity. Biochimie, 138, 184-193.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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