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Rabbit Anti-CNGA2 Recombinant Antibody (EG744) (CBMAB-EN899-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG744
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CNGA2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclic Nucleotide Gated Channel Alpha 2
Introduction
CNGA3 (Cyclic Nucleotide Gated Channel Alpha 3) is a Protein Coding gene. Diseases associated with CNGA3 include Achromatopsia 2 and Achromatopsia. Among its related pathways are cAMP signaling pathway and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and voltage-gated potassium channel activity. An important paralog of this gene is CNGA1.
Entrez Gene ID
Human1260
Mouse12789
Rat25411
UniProt ID
HumanQ16280
MouseQ62398
RatQ00195
Alternative Names
Cyclic Nucleotide Gated Channel Alpha 2; CNG Channel Alpha-2; CNCA1; CNCA; CNG2; Cyclic Nucleotide-Gated Olfactory Channel; Cyclic-Nucleotide-Gated Cation Channel 2; Cyclic Nucleotide-Gated Cation Channel 2;
Function
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Biological Process
Cilium assembly Source: Reactome
Response to stimulus Source: UniProtKB-KW
Sensory perception of smell Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-138
Helical: 139-159
Extracellular: 160-171
Helical: 172-192
Cytoplasmic: 193-224
Helical: 225-245
Extracellular: 246-274
Helical: 275-295
Cytoplasmic: 296-350
Helical: 351-371
Extracellular: 372-453
Helical: 454-474
Cytoplasmic: 475-662
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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