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Mouse Anti-CHIT1 Recombinant Antibody (CBXC-1172) (CBMAB-C5346-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1172
Antibody Isotype
IgG3
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human Chitotriosidase/CHIT1, Ala22-Asn466.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chitinase 1
Introduction
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
Entrez Gene ID
1118
UniProt ID
Q13231
Alternative Names
Chitinase 1; Chitinase 1 (Chitotriosidase); EC 3.2.1.14; Plasma Methylumbelliferyl Tetra-N-Acetylchitotetraoside Hydrolase; Chitotriosidase-1; Chitotriosidase;
Function
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Biological Process
Chitin catabolic process Source: UniProtKB
Immune response Source: UniProtKB
Neutrophil degranulation Source: Reactome
Polysaccharide catabolic process Source: UniProtKB-KW
Polysaccharide digestion Source: Reactome
Response to bacterium Source: ProtInc
Cellular Location
Secreted; Lysosome. A small proportion is lysosomal.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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