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Mouse Anti-CHGB Recombinant Antibody (BA0374) (CBMAB-0238CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
BA0374
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Recombinant human Chromogranin B Met1-Gly677.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chromogranin B
Introduction
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. Craig et al. (1986) assigned the chromogranin B gene to chromosome 20. Craig et al. (1987) showed by in situ hybridization that the CHGB locus is on 20pter-p12. Jenkins et al. (1991) mapped the murine gene, symbolized Scg-1, to chromosome 2 by in situ hybridization and by interspecific backcross analysis.
Entrez Gene ID
1114
UniProt ID
P05060
Alternative Names
Chromogranin B; Secretogranin B; Secretogranin I; Chromogranin-B; SCG1; CGB; SgI; Secretogranin 1
Function
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Biological Process
Cellular protein metabolic process Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Secreted. Neuroendocrine and endocrine secretory granules.
PTM
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
O-glycosylated.
More Infomation

Herold, Z., Herold, M., Rosta, K., Doleschall, M., & Somogyi, A. (2020). Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment. Diabetology & Metabolic Syndrome, 12(1), 1-5.

Bearrows, S. C., Bauchle, C. J., Becker, M., Haldeman, J. M., Swaminathan, S., & Stephens, S. B. (2019). Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. Journal of cell science, 132(13), jcs231373.

Stenman, A., Svahn, F., Hojjat-Farsangi, M., Zedenius, J., Söderkvist, P., Gimm, O., ... & Juhlin, C. C. (2019). Molecular profiling of pheochromocytoma and abdominal paraganglioma stratified by the PASS algorithm reveals chromogranin B as associated with histologic prediction of malignant behavior. The American journal of surgical pathology, 43(3), 409-421.

Yadav, G. P., Wang, H., Ouwendijk, J., Annamalai, M., Cross, S., Wang, Q., ... & Jiang, Q. X. (2019). Membrane insertion of chromogranin B for granule maturation in regulated secretion. bioRxiv.

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Bloom, L. B., & Jiang, Q. X. (2018). Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes. Life science alliance, 1(5).

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Annamalai, M., Bloom, L. B., ... & Jiang, Q. X. (2018). Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells. bioRxiv, 302828.

Shin, J. G., Kim, J. H., Park, C. S., Kim, B. J., Kim, J. W., Choi, I. G., ... & Woo, S. I. (2017). Gender-specific associations between CHGB genetic variants and schizophrenia in a Korean population. Yonsei medical journal, 58(3), 619-625.

Ohta, Y., Soucy, G. S., Phaneuf, D., Audet, J. N., Gros-Louis, F., Yamashita, T., ... & Abe, K. (2017). The role of variant chromogranin b as disease modifier in japanese female amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 381, 101.

Yadav, G. P., Yang, Q., & Jiang, Q. X. (2017). Chromogranin B Serves the Long-Sought-After Anion Conductance in Regulated Secretion. Biophysical Journal, 112(3), 184a.

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For research use only. Not intended for any clinical use.

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