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Rabbit Anti-CHGB Recombinant Antibody (CBWJC-2676) (CBMAB-C3768WJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBWJC-2676
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human Chromogranin B aa 601-650.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH7.4, 0.05% BSA, 40% Glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chromogranin B
Introduction
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
Entrez Gene ID
Human1114
Mouse12653
Rat24259
UniProt ID
HumanP05060
MouseP16014
RatO35314
Alternative Names
Chromogranin B; Secretogranin B; Secretogranin I; SCG1; CGB; SgI; Secretogranin 1; Secretogranin-1; Chromogranin-B;
Function
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Biological Process
Cellular protein metabolic process Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Secreted. Neuroendocrine and endocrine secretory granules.
PTM
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
O-glycosylated.
More Infomation

Herold, Z., Herold, M., Rosta, K., Doleschall, M., & Somogyi, A. (2020). Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment. Diabetology & Metabolic Syndrome, 12(1), 1-5.

Bearrows, S. C., Bauchle, C. J., Becker, M., Haldeman, J. M., Swaminathan, S., & Stephens, S. B. (2019). Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. Journal of cell science, 132(13), jcs231373.

Stenman, A., Svahn, F., Hojjat-Farsangi, M., Zedenius, J., Söderkvist, P., Gimm, O., ... & Juhlin, C. C. (2019). Molecular profiling of pheochromocytoma and abdominal paraganglioma stratified by the PASS algorithm reveals chromogranin B as associated with histologic prediction of malignant behavior. The American journal of surgical pathology, 43(3), 409-421.

Yadav, G. P., Wang, H., Ouwendijk, J., Annamalai, M., Cross, S., Wang, Q., ... & Jiang, Q. X. (2019). Membrane insertion of chromogranin B for granule maturation in regulated secretion. bioRxiv.

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Bloom, L. B., & Jiang, Q. X. (2018). Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes. Life science alliance, 1(5).

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Annamalai, M., Bloom, L. B., ... & Jiang, Q. X. (2018). Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells. bioRxiv, 302828.

Shin, J. G., Kim, J. H., Park, C. S., Kim, B. J., Kim, J. W., Choi, I. G., ... & Woo, S. I. (2017). Gender-specific associations between CHGB genetic variants and schizophrenia in a Korean population. Yonsei medical journal, 58(3), 619-625.

Ohta, Y., Soucy, G. S., Phaneuf, D., Audet, J. N., Gros-Louis, F., Yamashita, T., ... & Abe, K. (2017). The role of variant chromogranin b as disease modifier in japanese female amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 381, 101.

Yadav, G. P., Yang, Q., & Jiang, Q. X. (2017). Chromogranin B Serves the Long-Sought-After Anion Conductance in Regulated Secretion. Biophysical Journal, 112(3), 184a.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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