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Human Anti-CDH17 Recombinant Antibody (CBYJL-160) (CBMAB-L0238-YJ)


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Summary

Host Animal
Human
Specificity
Human
Clone
CBYJL-160
Antibody Isotype
IgG1
Application
ELISA, FC

Basic Information

Immunogen
CDH17.
Host Species
Human
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
8% sucrose, 0.01% Tween80
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cadherin 17
Introduction
Diseases associated with CDH17 include Gastric Adenocarcinoma and Gastric Cancer. Among its related pathways are Gastric cancer and ERK Signaling. Gene Ontology (GO) annotations related to this gene include proton-dependent oligopeptide secondary active transmembrane transporter activity and calcium ion binding. An important paralog of this gene is CDH16.
Entrez Gene ID
1015
UniProt ID
Q12864
Alternative Names
Cadherin 17; Intestinal Peptide-Associated Transporter HPT-1; Cadherin 17; LI Cadherin (Liver-Intestine); Liver-Intestine Cadherin; Human Intestinal Peptide-Associated Transporter HPT-1; Human Peptide Transporter 1; HPT-1 Cadherin; Cadherin-16
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
Biological Process
Adherens junction organization Source: Reactome
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Germinal center B cell differentiation Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Marginal zone B cell differentiation Source: Ensembl
Oligopeptide transmembrane transport Source: UniProtKB
Oligopeptide transport Source: UniProtKB
Positive regulation of integrin activation by cell surface receptor linked signal transduction Source: UniProtKB
Spleen development Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 23-787
Helical: 788-808
Cytoplasmic: 809-832
More Infomation

Gray, M. E., & Sotomayor, M. (2021). Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism. Acta Crystallographica Section F: Structural Biology Communications, 77(3).

Zheng, B., Shen, S., Wong, T. K., Gong, Z. J., Sun, W., Ni, X., ... & Suo, T. (2021). Clinical correlation of cadherin-17 (CA17 aka CDH17) marker with advanced tumor stages and poor prognosis of cholangiocarcinoma in a retrospective cohort of 180 patients.

Lum, Y. L., Luk, J. M., Staunton, D. E., Ng, D. K., & Fong, W. P. (2020). Cadherin-17 Targeted near-infrared photoimmunotherapy for treatment of gastrointestinal cancer. Molecular Pharmaceutics, 17(10), 3941-3951.

Atukorala, I., & Mathivanan, S. (2018). PO-066 Knockdown of cadherin 17 inactivates WNT signalling pathway and induces apoptosis in colorectal cancer cells. ESMO Open, 3, A47.

Chang, Y. Y., Yu, L. C. H., Yu, I. S., Jhuang, Y. L., Huang, W. J., Yang, C. Y., & Jeng, Y. M. (2018). Deletion of cadherin‐17 enhances intestinal permeability and susceptibility to intestinal tumour formation. The Journal of pathology, 246(3), 289-299.

Lee, C. W., Lin, S. E., Tsai, H. I., Su, P. J., Hsieh, C. H., Kuo, Y. C., ... & Yu, M. C. (2018). Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma. Oncology letters, 15(1), 559-567.

Tian, X., Han, Z., Zhu, Q., Tan, J., Liu, W., Wang, Y., ... & Huang, X. (2018). Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. Biomedicine & Pharmacotherapy, 108, 331-337.

Bian, T., Zhao, J., Feng, J., Zhang, Q., Qian, L., Liu, J., ... & Zhang, J. (2017). Combination of cadherin-17 and SATB homeobox 2 serves as potential optimal makers for the differential diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. Oncotarget, 8(38), 63442.

Shek, F. H., Luo, R., Lam, B. Y., Sung, W. K., Lam, T. W., Luk, J. M., ... & Lee, N. P. (2017). Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma. Cellular Oncology, 40(5), 443-456.

Smith, A. R., Rota, I. A., Maio, S., Massaad, M. J., Lund, T. C., Notarangelo, L. D., ... & Blazar, B. R. (2017). Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT. Blood advances, 1(23), 2083.

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For research use only. Not intended for any clinical use.

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