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Mouse Anti-CD99 Recombinant Antibody (CBYY-C1661) (CBMAB-C3099-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1661
Antibody Isotype
IgM
Application
FC, IHC-P, IP, WB

Basic Information

Immunogen
HPB-ALL human peripheral blood leukemia T-cell line.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
FC1 µg/ml
IHC-P10 µg/ml
IP1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD99 Molecule (Xg Blood Group)
Entrez Gene ID
4267
UniProt ID
P14209
Function
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
Biological Process
Homotypic cell-cell adhesion Source: GO_Central
Positive regulation of neutrophil extravasation Source: GO_Central
Regulation of immune response Source: Reactome
T cell extravasation Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 23-122
Helical: 123-147
Cytoplasmic: 148-185
PTM
Extensively O-glycosylated.
More Infomation

Siwy, J., Wendt, R., Albalat, A., He, T., Mischak, H., Mullen, W., ... & Beige, J. (2021). CD99 and polymeric immunoglobulin receptor peptides deregulation in critical COVID‐19: A potential link to molecular pathophysiology?. Proteomics, 21(20), 2100133.

Mattisson, J., Danielsson, M., Hammond, M., Davies, H., Gallant, C. J., Nordlund, J., ... & Forsberg, L. A. (2021). Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99. Scientific Reports, 11(1), 1-9.

Takheaw, N., Sittithumcharee, G., Kariya, R., Kasinrerk, W., & Okada, S. (2021). Anti-human CD99 antibody exerts potent antitumor effects in mantle cell lymphoma. Cancer Immunology, Immunotherapy, 70(6), 1557-1567.

Vaikari, V. P., Park, M., Keossayan, L., MacKay, J. A., & Alachkar, H. (2020). Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia. Nanomedicine: Nanotechnology, Biology and Medicine, 29, 102236.

Wu, J., Zhang, L., Li, H., Wu, S., & Liu, Z. (2019). Nrf2 induced cisplatin resistance in ovarian cancer by promoting CD99 expression. Biochemical and biophysical research communications, 518(4), 698-705.

Cardoso, L. C., Soares, R. D. S., Laurentino, T. D. S., Lerario, A. M., Marie, S. K., & Oba-Shinjo, S. M. (2019). CD99 expression in glioblastoma molecular subtypes and role in migration and invasion. International journal of molecular sciences, 20(5), 1137.

Pasello, M., Manara, M. C., & Scotlandi, K. (2018). CD99 at the crossroads of physiology and pathology. Journal of cell communication and signaling, 12(1), 55-68.

Çelik, H., Sciandra, M., Flashner, B., Gelmez, E., Kayraklıoğlu, N., Allegakoen, D. V., ... & Üren, A. (2018). Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99. Oncogene, 37(16), 2181-2196.

Manara, M. C., Pasello, M., & Scotlandi, K. (2018). CD99: a cell surface protein with an oncojanus role in tumors. Genes, 9(3), 159.

Yeh, C. C., Chang, C. J., Twu, Y. C., Chu, C. C., Liu, B. S., Huang, J. T., ... & Yu, L. C. (2018). The molecular genetic background leading to the formation of the human erythroid-specific Xga/CD99 blood groups. Blood advances, 2(15), 1854-1864.

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For research use only. Not intended for any clinical use.

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