Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CD80 Recombinant Antibody (3E10) (CBMAB-C5923-LY)


See all CD80 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E10
Antibody Isotype
IgM, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Full-length recombinant CD80.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD80 Molecule
Introduction
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
Entrez Gene ID
941
UniProt ID
P33681
Alternative Names
CD80 Molecule; CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen); B-Lymphocyte Activation Antigen B7; CTLA-4 Counter-Receptor B7.1; Activation B7-1 Antigen; CD28LG1; CD28LG; LAB7; BB1;
Function
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Cellular response to lipopolysaccharide Source: GO_Central
Cytokine-mediated signaling pathway Source: Reactome
Immune response Source: GO_Central
Intracellular signal transduction Source: UniProtKB
Negative regulation of T cell proliferation Source: GO_Central
Positive regulation of granulocyte macrophage colony-stimulating factor production Source: UniProtKB
Positive regulation of interleukin-2 production Source: UniProtKB
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein kinase B signaling Source: Reactome
Positive regulation of signal transduction Source: UniProtKB
Positive regulation of T cell proliferation Source: GO_Central
Positive regulation of T-helper 1 cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
T cell costimulation Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 35-242
Helical: 243-263
Cytoplasmic: 264-288
More Infomation

Tekguc, M., Wing, J. B., Osaki, M., Long, J., & Sakaguchi, S. (2021). Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells. Proceedings of the National Academy of Sciences, 118(30).

Zhao, Y., Lee, C. K., Lin, C. H., Gassen, R. B., Xu, X., Huang, Z., ... & Hui, E. (2019). PD-L1: CD80 cis-heterodimer triggers the co-stimulatory receptor CD28 while repressing the inhibitory PD-1 and CTLA-4 pathways. Immunity, 51(6), 1059-1073.

Haabeth, O. A. W., Blake, T. R., McKinlay, C. J., Tveita, A. A., Sallets, A., Waymouth, R. M., ... & Levy, R. (2019). Local delivery of Ox40l, Cd80, and Cd86 mRNA kindles global anticancer immunity. Cancer research, 79(7), 1624-1634.

Jiménez-Uribe, A. P., Valencia-Martínez, H., Carballo-Uicab, G., Vallejo-Castillo, L., Medina-Rivero, E., Chacón-Salinas, R., ... & Pérez-Tapia, S. M. (2019). CD80 expression correlates with IL-6 production in THP-1-like macrophages costimulated with LPS and dialyzable leukocyte extract (Transferon®). Journal of immunology research, 2019.

Kleinpeter, P., Remy-Ziller, C., Winter, E., Gantzer, M., Nourtier, V., Kempf, J., ... & Marchand, J. B. (2019). By binding CD80 and CD86, the vaccinia virus M2 protein blocks their interactions with both CD28 and CTLA4 and potentiates CD80 binding to PD-L1. Journal of virology, 93(11), e00207-19.

Li, W., Kim, T. I., Kim, J. H., & Chung, H. S. (2019). Immune checkpoint PD-1/PD-L1 CTLA-4/CD80 are blocked by Rhus verniciflua Stokes and its active compounds. Molecules, 24(22), 4062.

Huang, Y., Wang, Z., Zheng, Q., Tang, J., Cai, J., Lu, Y., & Jian, J. (2018). Conservation of structural and interactional features of CD28 and CD80/86 molecules from Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology, 72, 95-103.

Siokis, A., Robert, P. A., Demetriou, P., Dustin, M. L., & Meyer-Hermann, M. (2018). F-actin-driven CD28-CD80 localization in the immune synapse. Cell reports, 24(5), 1151-1162.

Bengsch, F., Knoblock, D. M., Liu, A., McAllister, F., & Beatty, G. L. (2017). CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer. Cancer Immunology, Immunotherapy, 66(12), 1609-1617.

Mo, Z. Q., Wang, J. L., Yang, M., Ni, L. Y., Wang, H. Q., Lao, G. F., ... & Dan, X. M. (2017). Characterization and expression analysis of grouper (Epinephelus coioides) co-stimulatory molecules CD83 and CD80/86 post Cryptocaryon irritans infection. Fish & shellfish immunology, 67, 467-474.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CD80 Recombinant Antibody (3E10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry