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Rat Anti-CD69 Recombinant Antibody (310106) (CBMAB-C0942-LY)

This product is antibody recognizes CD69. The antibody 310106 immunoassay techniques such as: WB, ICC.
See all CD69 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
310106
Antibody Isotype
IgG1
Application
WB, ICC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CD69, Gly64-Arg199, Accession # P37217
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD69 Molecule
Introduction
CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include Coccidioidomycosis and Asthma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Kit receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and carbohydrate binding.
An important paralog of this gene is CLEC2A.
Entrez Gene ID
12515
UniProt ID
P37217
Function
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
Cellular Location
Membrane
Topology
Cytoplasmic: 1-40
Helical: 41-61
Extracellular: 62-199
PTM
Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Gorabi, A. M., Hajighasemi, S., Kiaie, N., Hayat, S. M. G., Jamialahmadi, T., Johnston, T. P., & Sahebkar, A. (2020). The pivotal role of CD69 in autoimmunity. Journal of autoimmunity, 111, 102453.

Notario, L., Redondo-Antón, J., Alari-Pahissa, E., Albentosa, A., Leiva, M., Lopez, D., ... & Lauzurica, P. (2019). CD69 targeting enhances anti-vaccinia virus immunity. Journal of virology, 93(19), e00553-19.

Kimura, M. Y., Koyama-Nasu, R., Yagi, R., & Nakayama, T. (2019, May). A new therapeutic target: the CD69-Myl9 system in immune responses. In Seminars in immunopathology (Vol. 41, No. 3).

Walsh, D. A., Da Silva, H. B., Beura, L. K., Peng, C., Hamilton, S. E., Masopust, D., & Jameson, S. C. (2019). The functional requirement for CD69 in establishment of resident memory CD8+ T cells varies with tissue location. The Journal of Immunology, 203(4), 946-955.

Brait, V. H., Miró-Mur, F., Pérez-de-Puig, I., Notario, L., Hurtado, B., Pedragosa, J., ... & Planas, A. M. (2019). CD69 plays a beneficial role in ischemic stroke by dampening endothelial activation. Circulation research, 124(2), 279-291.

Mita, Y., Kimura, M. Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., ... & Nakayama, T. (2018). Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. International immunology, 30(12), 559-567.

Kimura, M. Y., Igi, A., Hayashizaki, K., Mita, Y., Shinzawa, M., Kadakia, T., ... & Nakayama, T. (2018). CD69 prevents PLZF hi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. Nature communications, 9(1), 1-12.

Cibrián, D., & Sánchez‐Madrid, F. (2017). CD69: from activation marker to metabolic gatekeeper. European journal of immunology, 47(6), 946-953.

Yong, Y. K., Tan, H. Y., Saeidi, A., Rosmawati, M., Atiya, N., Ansari, A. W., ... & Shankar, E. M. (2017). Decrease of CD69 levels on TCR Vα7. 2+ CD4+ innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients. Innate immunity, 23(5), 459-467.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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