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Mouse Anti-CD68 Recombinant Antibody (EC113) (V2LY-0624-LY113)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EC113
Antibody Isotype
IgG
Application
IHC-P, IF

Basic Information

Immunogen
Synthetic Peptide.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:100-1:300
IF(CC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD68 Molecule
Introduction
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
Entrez Gene ID
Human968
Mouse12514
Rat287435
UniProt ID
HumanP34810
MouseP31996
RatQ4FZY1
Alternative Names
CD68 Molecule; CD68 Antigen; Scavenger Receptor Class D, Member 1; Macrophage Antigen CD68; GP110; Macrosialin; SCARD1; LAMP4;
Function
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Biological Process
Aging Source: ARUK-UCL
Autocrine signaling Source: Ensembl
Cellular response to lipopolysaccharide Source: ARUK-UCL
Cellular response to nutrient levels Source: ARUK-UCL
Cellular response to oxidised low-density lipoprotein particle stimulus Source: ARUK-UCL
Establishment of protein localization to organelle Source: GO_Central
Inflammatory response to antigenic stimulus Source: ARUK-UCL
Negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
Neutrophil degranulation Source: Reactome
Cellular Location
Isoform Short: Cell membrane
Isoform Long: Lysosome membrane; Endosome membrane
Topology
Extracellular: 22-319
Helical: 320-344
Cytoplasmic: 345-354
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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