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Mouse Anti-CD68 Recombinant Antibody (CBFYC-1396) (CBMAB-C1454-FY)


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Published Data
CBMAB-C1454-FY-1
Mouse Anti-CD68 Recombinant Antibody (CBFYC-1396) (CBMAB-C1454-FY) in IF
Immunofluorescence detection of CD68 and CD206 proteins of all groups (200 ×) (n = 6). ...View More
Yi, Z., Jia, Q., Wang, Y., Zhang, Y., Xie, T., & Ling, J. (2023). Elian granules alleviate precancerous lesions of gastric cancer in rats by suppressing M2-type polarization of tumor-associated macrophages through NF-κB signaling pathway. BMC Complementary Medicine and Therapies, 23(1), 188. Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1454-FY-2
Mouse Anti-CD68 Recombinant Antibody (CBFYC-1396) (CBMAB-C1454-FY) in IHC
Immunostaining for CD68+ cells and Mayer's hematoxylin for nuclei, magnification ×400. (a) Intact control; (b) LPS-control; (c) LPS + 5 mg/kg dexamethasone; (d) LPS + 30 mg/kg 6e. ...View More
Spasov, A., Ovchinnikova, I., Fedorova, O., Titova, Y., Babkov, D., Kosolapov, V., ... & Charushin, V. (2023). Amino derivatives of diaryl pyrimidines and azolopyrimidines as protective agents against LPS-induced acute lung injury. Molecules, 28(2), 741. Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1454-FY-3
Mouse Anti-CD68 Recombinant Antibody (CBFYC-1396) (CBMAB-C1454-FY) in IHC
Immunohistochemistry staining for CD68 indicates the presence of a low number of Kupffer cells (arrow heads). ...View More
Zandi Shafagh, R., Youhanna, S., Keulen, J., Shen, J. X., Taebnia, N., Preiss, L. C., ... & Lauschke, V. M. (2022). Bioengineered pancreas-liver crosstalk in a microfluidic coculture chip identifies human metabolic response signatures in prediabetic hyperglycemia. Advanced Science, 9(34), 2203368. Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1454-FY-4
Mouse Anti-CD68 Recombinant Antibody (CBFYC-1396) (CBMAB-C1454-FY) in WB
Western blot analysis of P3C4 treated with or without GSK-KI helped assess the phosphorylation levels at S1292 in LRRK2 and CD68. ...View More
Ho, D. H., Nam, D., Seo, M., Park, S. W., Seol, W., & Son, I. (2022). LRRK2 inhibition mitigates the neuroinflammation caused by TLR2-specific α-Synuclein and alleviates neuroinflammation-derived dopaminergic neuronal loss. Cells, 11(5), 861. Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C1454-FY-5
Mouse Anti-CD68 Recombinant Antibody (CBFYC-1396) (CBMAB-C1454-FY) in IHC
Immunohistochemical labeling of CD68 on controlateral implantation of GlioGel containing a combination of the three chemoattractants. Unusual intracellular cell marking, mostly at the superficial periphery of the tumor implantation site. ...View More
Déry, L., Charest, G., Guérin, B., Akbari, M., & Fortin, D. (2021). Chemoattraction of neoplastic glial cells with CXCL10, CCL2 and CCL11 as a paradigm for a promising therapeutic approach for primary brain tumors. International Journal of Molecular Sciences, 22(22), 12150. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-1396
Antibody Isotype
IgG1, κ
Application
IP, IF, WB, FC, IHC-P

Basic Information

Immunogen
Subcellular fraction of human alveolar macrophages.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD68 Molecule
Introduction
CD68 (CD68 Molecule) is a Protein Coding gene. Diseases associated with CD68 include Granular Cell Tumor and Breast Granular Cell Tumor. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. An important paralog of this gene is LAMP1.
Entrez Gene ID
968
UniProt ID
P34810
Alternative Names
CD68 Molecule; CD68 Antigen; Scavenger Receptor Class D, Member 1; Macrophage Antigen CD68; GP110; Macrosialin; SCARD1; LAMP4;
Function
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Biological Process
Aging Source: ARUK-UCL
Autocrine signaling Source: Ensembl
Cellular response to lipopolysaccharide Source: ARUK-UCL
Cellular response to nutrient levels Source: ARUK-UCL
Cellular response to oxidised low-density lipoprotein particle stimulus Source: ARUK-UCL
Establishment of protein localization to organelle Source: GO_Central
Inflammatory response to antigenic stimulus Source: ARUK-UCL
Negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
Neutrophil degranulation Source: Reactome
Cellular Location
Isoform Short: Cell membrane
Isoform Long: Lysosome membrane; Endosome membrane
Topology
Extracellular: 22-319
Helical: 320-344
Cytoplasmic: 345-354
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

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