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Rat Anti-CD1D Recombinant Antibody (1B1) (CBMAB-C0475-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
1B1
Antibody Isotype
IgG2b
Application
FC, IP, IHC

Basic Information

Immunogen
Mouse CD1d cDNA-transfected RMA-S mouse T lymphoma.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC1:10-1:20

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD1d Molecule
Introduction
CD1D (CD1d Molecule) is a Protein Coding gene. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease. Among its related pathways are Innate Immune System and Amoebiasis. Gene Ontology (GO) annotations related to this gene include receptor activity and cell adhesion molecule binding.
An important paralog of this gene is CD1E.
Entrez Gene ID
12479
UniProt ID
P11609
Alternative Names
CD1d Molecule; CD1D Antigen, D Polypeptide; CD1d Antigen; R3G1; HMC Class I Antigen-Like Glycoprotein CD1D; Antigen-Presenting Glycoprotein CD1d;
Function
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: UniProtKB
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Detection of bacterium Source: UniProtKB
Heterotypic cell-cell adhesion Source: BHF-UCL
Innate immune response Source: UniProtKB-KW
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Positive regulation of T cell proliferation Source: BHF-UCL
Regulation of immune response Source: Reactome
T cell selection Source: UniProtKB
Cellular Location
Lysosome membrane; Endoplasmic reticulum membrane; Endosome membrane; Cell membrane; Basolateral cell membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
Topology
Extracellular: 20-301
Helical: 302-322
Cytoplasmic: 323-335
More Infomation

Medved, J., Knott, B. M., Tarrah, S. N., Li, A. N., Shah, N., Moscovich, T. C., ... & Luckey, C. J. (2021). The lysophospholipid‐binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. Transfusion, 61(7), 2169-2178.

Lameris, R., Shahine, A., Pellicci, D. G., Uldrich, A. P., Gras, S., Le Nours, J., ... & van der Vliet, H. J. (2020). A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response. Nature Cancer, 1(11), 1054-1065.

Almeida, C. F., Sundararaj, S., Le Nours, J., Praveena, T., Cao, B., Burugupalli, S., ... & Rossjohn, J. (2019). Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nature communications, 10(1), 1-14.

Qin, Y., Oh, S., Lim, S., Shin, J. H., Yoon, M. S., & Park, S. H. (2019). Invariant NKT cells facilitate cytotoxic T-cell activation via direct recognition of CD1d on T cells. Experimental & molecular medicine, 51(10), 1-9.

Iwamura, C., & Nakayama, T. (2018). Role of CD1d-and MR1-restricted T cells in asthma. Frontiers in immunology, 9, 1942.

King, L. A., Lameris, R., de Gruijl, T. D., & van der Vliet, H. J. (2018). CD1d-invariant natural killer T cell-based cancer immunotherapy: α-Galactosylceramide and beyond. Frontiers in immunology, 9, 1519.

Huh, J. Y., Park, Y. J., & Kim, J. B. (2018). Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity. Adipocyte, 7(2), 129-136.

Brutkiewicz, R. R., Yunes-Medina, L., & Liu, J. (2018). Immune evasion of the CD1d/NKT cell axis. Current opinion in immunology, 52, 87-92.

Rizvi, Z. A., Puri, N., & Saxena, R. K. (2018). Evidence of CD1d pathway of lipid antigen presentation in mouse primary lung epithelial cells and its up-regulation upon Mycobacterium bovis BCG infection. Plos one, 13(12), e0210116.

Brennan, P. J., Cheng, T. Y., Pellicci, D. G., Watts, G. F., Veerapen, N., Young, D. C., ... & Moody, D. B. (2017). Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface. Proceedings of the National Academy of Sciences, 114(31), 8348-8353.

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For research use only. Not intended for any clinical use.

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