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Mouse Anti-CD151 Recombinant Antibody (210127) (CBMAB-C0595-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
210127
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human CD151, Met1-Tyr253.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC2.5 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD151 Molecule (Raph Blood Group)
Introduction
CD151 (CD151 Molecule (Raph Blood Group)) is a Protein Coding gene. Diseases associated with CD151 include Nephropathy With Pretibial Epidermolysis Bullosa And Deafness and Raph Blood Group System. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include integrin binding.
An important paralog of this gene is TSPAN11.
Entrez Gene ID
977
UniProt ID
P48509
Alternative Names
CD151 Molecule (Raph Blood Group); CD151 Antigen; Platelet-Endothelial Tetraspan Antigen 3; CD151 Antigen (Raph Blood Group); Membrane Glycoprotein SFA-1; Tetraspanin-24; Tspan-24; TSPAN24; PETA-3;
Function
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
Biological Process
Cell adhesion Source: ProtInc
Cell migration Source: GO_Central
Collagen fibril organization Source: Reactome
Hemidesmosome assembly Source: Reactome
Positive regulation of cell migration Source: MGI
Positive regulation of endocytosis Source: MGI
T cell proliferation Source: Ensembl
Viral process Source: UniProtKB-KW
Wound healing, spreading of cells Source: MGI
Cellular Location
Membrane
Involvement in disease
Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD): A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.
Topology
Cytoplasmic: 1-18
Helical: 19-39
Extracellular: 40-57
Helical: 58-78
Cytoplasmic: 79-91
Helical: 92-112
Extracellular: 113-221
Helical: 222-242
Cytoplasmic: 243-253
PTM
Palmitoylated. Palmitoylation by ZDHHC2 regulates CD151 expression, association with other tetraspanin family proteins and function in cell adhesion.
More Infomation

Gao, C., Jia, W., Xu, W., Wu, Q., & Wu, J. (2021). Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke. Journal of neuroinflammation, 18(1), 1-16.

Jankovicova, J., Frolikova, M., Palenikova, V., Valaskova, E., Cerny, J., Secova, P., ... & Komrskova, K. (2020). Expression and distribution of CD151 as a partner of alpha6 integrin in male germ cells. Scientific reports, 10(1), 1-12.

Akella, M., & Malla, R. (2020). Molecular modeling and in vitro study on pyrocatechol as potential pharmacophore of CD151 inhibitor. Journal of Molecular Graphics and Modelling, 100, 107681.

Wong, A. H., & Tran, T. (2020). CD151 in respiratory diseases. Frontiers in cell and developmental biology, 8, 64.

Hwang, S., Takimoto, T., & Hemler, M. E. (2019). Integrin-independent support of cancer drug resistance by tetraspanin CD151. Cellular and Molecular Life Sciences, 76(8), 1595-1604.

Tao, Y., Zhang, H., Huang, S., Pei, L., Feng, M., Zhao, X., ... & Wei, K. (2019). miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression. Biochemical and biophysical research communications, 516(1), 28-36.

Gavara, M. M., Zaveri, K., Badana, A. K., Gugalavath, S., Amajala, K. C., Patnala, K., & Malla, R. R. (2018). A novel small molecule inhibitor of CD151 inhibits proliferation of metastatic triple negative breast cancer cell lines. Process Biochemistry, 66, 254-262.

Zhao, K., Wang, Z., Hackert, T., Pitzer, C., & Zöller, M. (2018). Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression. Journal of Experimental & Clinical Cancer Research, 37(1), 1-23.

Vahidnezhad, H., Youssefian, L., Saeidian, A. H., Mahmoudi, H., Touati, A., Abiri, M., ... & Uitto, J. (2018). Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy. Matrix Biology, 66, 22-33.

Naudin, C., Smith, B., Bond, D. R., Dun, M. D., Scott, R. J., Ashman, L. K., ... & Roselli, S. (2017). Characterization of the early molecular changes in the glomeruli of Cd151−/− mice highlights induction of mindin and MMP-10. Scientific reports, 7(1), 1-12.

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For research use only. Not intended for any clinical use.

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