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Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY)


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Published Data
CBMAB-C2450-LY-1
Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in WB
Representative capillary westerns showing the reactivity of the mouse anti-CARTp antibody against different amounts of synthetic CARTp and scrambled CARTp. ...View More
Kobori, N., Moore, A. N., Redell, J. B., & Dash, P. K. (2023). Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function. Journal of Neuroinflammation, 20(1), 158.
CBMAB-C2450-LY-2
Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in IHC
nNOS-positive nerves (nNOS+ green) immunoreactive to cocaine- and amphetamine-regulated transcript (CART) (red) in the: (I) muscular layer of the corpus, (II) mucosal layer of the corpus, (III) muscular layer of the horns, (IV) mucosal layer of the horns of the uterine body of control animals (A) and pigs treated with low (B) and high (C) dose of bisphenol A. Nerves simultaneously immunoreactive to nNOS and CART (yellow) are indicated with arrowheads. ...View More
Rytel, L., & Gonkowski, S. (2020). The influence of bisphenol a on the nitrergic nervous structures in the domestic porcine uterus. International Journal of Molecular Sciences, 21(12), 4543.
CBMAB-C2450-LY-3
Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in IHC
Triple staining of the neuronal marker UCHL1 and two different TRPV1 antibodies derived from rabbit and goat, respectively, to facilitate the analysis of various targets. The staining intensities obtained with both TRPV1 antibodies correlated significantly (Spearmans ρ = 0.96, p<2.2e-16). Co-labeling of TRPV1 and CART. ...View More
Isensee, J., Wenzel, C., Buschow, R., Weissmann, R., Kuss, A. W., & Hucho, T. (2014). Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS One, 9(12), e115731.
CBMAB-C2450-LY-4
Mouse Anti-CARTPT Recombinant Antibody (113612) (CBMAB-C2450-LY) in IHC
Immunostaining for CART, Calbindin and Parvalbumin in a retinal sections of MTN injected mice. ...View More
Ruff, T., Peters, C., Matsumoto, A., Ihle, S. J., Morales, P. A., Gaitanos, L., ... & Klein, R. (2021). FLRT3 marks direction-selective retinal ganglion cells that project to the medial terminal nucleus. Frontiers in Molecular Neuroscience, 14, 790466.

Summary

Host Animal
Mouse
Specificity
Human
Clone
113612
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
E. coli-derived recombinant human CART, Ala37-Leu116.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CART Prepropeptide
Introduction
This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]
Entrez Gene ID
9607
UniProt ID
Q16568
Alternative Names
CART Prepropeptide; CART; Cocaine- And Amphetamine-Regulated Transcript Protein; Cocaine And Amphetamine Regulated Transcript;
Function
Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.
Biological Process
Activation of MAPKK activity Source: HGNC-UCL
Adult feeding behavior Source: HGNC-UCL
Cell-cell signaling Source: ProtInc
Cellular glucose homeostasis Source: HGNC-UCL
Cellular response to starvation Source: HGNC-UCL
Chemical synaptic transmission Source: UniProtKB-KW
Circadian regulation of gene expression Source: HGNC-UCL
G protein-coupled receptor signaling pathway Source: HGNC-UCL
Negative regulation of appetite Source: HGNC-UCL
Negative regulation of bone resorption Source: HGNC-UCL
Negative regulation of glucagon secretion Source: Ensembl
Negative regulation of osteoclast differentiation Source: HGNC-UCL
Neuropeptide signaling pathway Source: UniProtKB-KW
Positive regulation of blood pressure Source: HGNC-UCL
Positive regulation of epinephrine secretion Source: HGNC-UCL
Positive regulation of transmission of nerve impulse Source: HGNC-UCL
Regulation of insulin secretion Source: Ensembl
Signal transduction Source: ProtInc
Somatostatin secretion Source: Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

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