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Rabbit Anti-BRD3 Recombinant Antibody (EG411) (CBMAB-EN469-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG411
Antibody Isotype
IgG
Application
WB, IF, IH

Basic Information

Immunogen
Immunogen was a peptide representing a region between residue 676 and 726 of human Bromodomain-containing protein 3.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:100-1:500
IHC1:100-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BBS, pH 8.2, 0.1% BSA
Preservative
0.09% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bromodomain Containing 3
Introduction
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human8019
Mouse67382
UniProt ID
HumanQ15059
MouseQ8K2F0
Alternative Names
Bromodomain Containing 3; RING3-Like Protein; RING3L; Bromodomain-Containing Protein 3 Short Isoform; Bromodomain-Containing Protein 3; Bromodomain-Containing 3; RING3-Like; KIAA0043; ORFX;
Function
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114).
Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity).
Biological Process
Chromatin organization Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus. Detected on chromatin.
Involvement in disease
A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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