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Mouse Anti-BRD1 Recombinant Antibody (CBYY-1950) (CBMAB-2299-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1950
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to a region near the C-terminus of BMS1 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BRD1
Introduction
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
23774
UniProt ID
O95696
Alternative Names
Bromodomain Containing 1; Bromodomain And PHD Finger-Containing Protein 2; BR140-Like Protein; BRPF2; BRL; Bromodomain-Containing Protein 1; Bromodomain-Containing 1; BR140-Like; BRPF1;
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189).
Biological Process
Erythrocyte maturation Source: UniProtKB-KW
Histone H3 acetylation Source: UniProtKB
Histone H3-K14 acetylation Source: UniProtKB
Histone H3-K23 acetylation Source: GOC
Positive regulation of erythrocyte differentiation Source: UniProtKB
Response to electrical stimulus Source: Ensembl
Response to immobilization stress Source: Ensembl
Cellular Location
Nucleus; Chromosome. Localizes to transcription start sites.
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For research use only. Not intended for any clinical use.

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