Mouse Anti-BRD1 Antibody (12B2) (CBMAB-0169-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

12B2

Antibody Isotype

IgG2a

Application

Basic Information

Immunogen

Recombinant protein

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

BRD1

Introduction

BRD1 (bromodomain containing 1) is a a component of the MOZ/MORF acetyltransferase complex that localizes to the nucleus and can interact with DNA and histone tails. BRD1 can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations.

Entrez Gene ID

23774

UniProt ID

O95696

Alternative Names

Bromodomain Containing 1; Bromodomain And PHD Finger-Containing Protein 2; BR140-Like Protein; BRPF2; BRL; Bromodomain-Containing; BR140-Like; BRPF1

Function

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189).

Biological Process

Erythrocyte maturation Source: UniProtKB-KW
Histone H3 acetylation Source: UniProtKB
Histone H3-K14 acetylation Source: UniProtKB
Histone H3-K23 acetylation Source: GOC
Positive regulation of erythrocyte differentiation Source: UniProtKB
Response to electrical stimulus Source: Ensembl
Response to immobilization stress Source: Ensembl

Cellular Location

Nucleus; Chromosome. Localizes to transcription start sites.

More Infomation

References

Yu, Y., Fu, W., Xu, J., Lei, Y., Song, X., Liang, Z., ... & Li, C. (2021). Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis. Molecular Plant.

Jarończyk, K., Sosnowska, K., Zaborowski, A., Pupel, P., Bucholc, M., Małecka, E., ... & Archacki, R. (2021). Bromodomain-containing subunits BRD1, BRD2, and BRD13 are required for proper functioning of SWI/SNF complexes in Arabidopsis. Plant Communications, 100174.

Li, Z., Wang, J., Ji, Y., & Song, F. (2021). Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples. Technology in cancer research & treatment, 20, 15330338211039678.

Paternoster, V., Edhager, A. V., Qvist, P., Donskov, J. G., Shliaha, P., Jensen, O. N., ... & Christensen, J. H. (2021). Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping. Molecular Neurobiology, 1-11.

Klein, K., Kato, M., Frank-Bertoncelj, M., Kolling, C., Ciurea, A., Gay, S., & Ospelt, C. (2018). Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis. Scientific reports, 8(1), 1-7.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-BRD1 Antibody (1B5)

Mouse Anti-BRD1 Antibody (2E4)

Mouse Anti-BRD1 Recombinant Antibody (CBYY-1946)

Mouse Anti-BRD1 Recombinant Antibody (CBYY-1950)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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