Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-BCL2L2 Recombinant Antibody (CBYY-0427) (CBMAB-0429-YY)


See all BCL2L2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0427
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human full-length BCL-W/BCL2L2 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1-2 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2 Like 2
Introduction
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Entrez Gene ID
599
UniProt ID
Q92843
Alternative Names
BCL2 Like 2; Protein Phosphatase 1, Regulatory Subunit 51; Bcl2-L-2; BCLW; Apoptosis Regulator Bcl-W; Apoptosis Regulator BCL-W;
Function
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Biological Process
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Spermatogenesis Source: ProtInc
Cellular Location
Mitochondrion membrane; Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
More Infomation

Li, Y., Li, X., Wang, L., Han, N., & Yin, G. (2021). miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells. Biotechnology Letters, 43(2), 353-367.

Yu, T., Yu, J., Lu, L., Zhang, Y., Zhou, Y., Zhou, Y., ... & Wang, B. (2021). MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis. Cellular Oncology, 1-14.

Zhang, M., & Cheng, K. (2021). Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis. Experimental Eye Research, 206, 108543.

Liu, H. N., Tang, X. M., Wang, X. Q., Gao, J., Li, N., Wang, Y. Y., & Xia, H. F. (2020). MiR-93 inhibits trophoblast cell proliferation and promotes cell apoptosis by targeting BCL2L2 in recurrent spontaneous abortion. Reproductive Sciences, 27(1), 152-162.

Ming, M., Ying, M., & Ling, M. (2019). miRNA‑125a‑5p inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting TP53 regulated inhibitor of apoptosis 1 and Bcl‑2‑like‑2 protein. Experimental and therapeutic medicine, 18(2), 1196-1202.

Zhang, N., Meng, X., Mei, L., Hu, J., Zhao, C., & Chen, W. (2018). The long non-coding RNA SNHG1 attenuates cell apoptosis by regulating miR-195 and BCL2-like protein 2 in human cardiomyocytes. Cellular Physiology and Biochemistry, 50(3), 1029-1040.

Wang, C., Zhou, B., Liu, M., Liu, Y., & Gao, R. (2017). miR-126-5p restoration promotes cell apoptosis in cervical cancer by targeting Bcl2l2. Oncology research, 25(4), 463.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BCL2L2 Recombinant Antibody (CBYY-0427)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry