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Mouse Anti-BCL2L2 Recombinant Antibody (2E4) (CBMAB-1207-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2E4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IP

Basic Information

Immunogen
Recombinant protein corresponding to amino acids 1-193 representing full length Bcl-w of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2 Like 2
Introduction
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Diseases associated with BCL2L2 include Small Intestinal Adenocarcinoma. Among its related pathways are Photodynamic therapy-induced NF-kB survival signaling and Apoptosis Modulation and Signaling. GO annotations related to this gene include protein homodimerization activity and BH domain binding. An important paralog of this gene is BCL2L1.
Entrez Gene ID
Human599
Monkey100611631
UniProt ID
HumanQ92843
MonkeyK7C6D4
Alternative Names
BCLW; BCL-W; PPP1R51; BCL2-L-2
Function
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Biological Process
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Spermatogenesis Source: ProtInc
Cellular Location
Mitochondrion membrane; Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
More Infomation

Li, Y., Li, X., Wang, L., Han, N., & Yin, G. (2021). miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells. Biotechnology Letters, 43(2), 353-367.

Yu, T., Yu, J., Lu, L., Zhang, Y., Zhou, Y., Zhou, Y., ... & Wang, B. (2021). MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis. Cellular Oncology, 1-14.

Zhang, M., & Cheng, K. (2021). Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis. Experimental Eye Research, 206, 108543.

Liu, H. N., Tang, X. M., Wang, X. Q., Gao, J., Li, N., Wang, Y. Y., & Xia, H. F. (2020). MiR-93 inhibits trophoblast cell proliferation and promotes cell apoptosis by targeting BCL2L2 in recurrent spontaneous abortion. Reproductive Sciences, 27(1), 152-162.

Ming, M., Ying, M., & Ling, M. (2019). miRNA‑125a‑5p inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting TP53 regulated inhibitor of apoptosis 1 and Bcl‑2‑like‑2 protein. Experimental and therapeutic medicine, 18(2), 1196-1202.

Zhang, N., Meng, X., Mei, L., Hu, J., Zhao, C., & Chen, W. (2018). The long non-coding RNA SNHG1 attenuates cell apoptosis by regulating miR-195 and BCL2-like protein 2 in human cardiomyocytes. Cellular Physiology and Biochemistry, 50(3), 1029-1040.

Wang, C., Zhou, B., Liu, M., Liu, Y., & Gao, R. (2017). miR-126-5p restoration promotes cell apoptosis in cervical cancer by targeting Bcl2l2. Oncology research, 25(4), 463.

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For research use only. Not intended for any clinical use.

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