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Rabbit Anti-BCL11A Recombinant Antibody (CBYY-C0768) (CBMAB-C2204-YY)


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Published Data
Rabbit Anti-BCL11A Recombinant Antibody (CBYY-C0768) (CBMAB-C2204-YY) in Immunoblot
Specific depletion of targeted Lmo2, Zbtb1, and Cbfa2t3 proteins. sgRNA against Lmo2, Zbtb1, Cbfa2t2, or Cbfa2t3 was introduced into the Cas9-expressing (GFP+) LPs. Four days after sgRNA transduction, nuclear
lysates from retrovirus infected GFP+hNGFR+ cells were subjected to immunoblotting for Lmo2, Zbtb1, Cbfa2t3, Bcl11a, and LaminB. Two independent experiments were performed with similar results. ...View More
Koizumi, M., Kama, Y., Hirano, K. I., Endo, Y., Tanaka, T., Hozumi, K., & Hosokawa, H. (2022). Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells. Journal of Biological Chemistry, 298(11).

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYY-C0768
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Val247 of human BCL11A protein.
Host Species
Rabbit
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IP1:200
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM HEPES, pH 7.5, 0.15M NaCl, 0.1mg/mL BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
B Cell CLL/Lymphoma 11A
Entrez Gene ID
53335
UniProt ID
Q9H165
Alternative Names
Complement C1r Subcomponent Like; Complement Component 1, R Subcomponent-Like; C1r-Like Serine Protease Analog Protein; C1r-Like Protein; C1r-LP; C1RL1; C1RLP;
Function
Transcription factor (PubMed:16704730, PubMed:29606353).
Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491).
Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353).
Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765).
Involved in brain development (PubMed:27453576).
May play a role in hematopoiesis (By similarity).
Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity).
May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
Biological Process
Cellular response to L-glutamate Source: Ensembl
Negative regulation of axon extension Source: BHF-UCL
Negative regulation of branching morphogenesis of a nerve Source: Ensembl
Negative regulation of collateral sprouting Source: BHF-UCL
Negative regulation of dendrite development Source: BHF-UCL
Negative regulation of dendrite extension Source: Ensembl
Negative regulation of neuron projection development Source: BHF-UCL
Negative regulation of neuron remodeling Source: Ensembl
Negative regulation of protein homooligomerization Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of collateral sprouting Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron projection development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein sumoylation Source: UniProtKB
Regulation of dendrite development Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Cytoplasm; Nucleus; Chromosome. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity).
Isoform 1: Nucleus matrix. Colocalizes with BCL6 in nuclear paraspeckles.
Isoform 2: Cytoplasm; Nucleus. Predominantly localized in the nucleus in nuclear paraspeckles.
Isoform 3: Cytoplasm; Nucleus. Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles.
Involvement in disease
Chromosomal aberrations involving BCL11A are associated with B-cell malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and overexpression.
Intellectual developmental disorder with persistence of fetal hemoglobin (IDPFH): An autosomal dominant disorder characterized by delayed psychomotor development, intellectual disability, variable dysmorphic features, including microcephaly, downslanting palpebral fissures, strabismus, and external ear abnormalities, and asymptomatic persistence of fetal hemoglobin.
PTM
Sumoylated with SUMO1.
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For research use only. Not intended for any clinical use.

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