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Mouse Anti-BCL11A Recombinant Antibody (1G10) (CBMAB-0159-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G10
Antibody Isotype
IgG2a
Application
WB, ELISA, FC, IF, IP

Basic Information

Immunogen
Recombinant full-length human Ctip1 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1-2 μg/ml
FC1-2 μg/10^6 cells
IF(ICC)1-2 μg/ml
IP1-2 μg/100-500 μg protein

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
B Cell CLL/Lymphoma 11A
Introduction
B-cell lymphoma/leukemia 11A (BCL11A) is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. BCL11A has been found to play a role in the suppression of fetal hemoglobin production. Therapeutic strategies aimed at increasing fetal globin production in diseases such as beta thalassemia and sickle cell anemia by inhibiting BCL11A are currently being explored.
Entrez Gene ID
53335
UniProt ID
Q9H165
Alternative Names
BCL11A-L; BCL11A-S; BCL11A-XL; CTIP1; EVI9; HBFQTL5; ZNF856
Function
Transcription factor (PubMed:16704730, PubMed:29606353).
Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491).
Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353).
Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765).
Involved in brain development (PubMed:27453576).
May play a role in hematopoiesis (By similarity).
Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity).
May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity).
Biological Process
Cellular response to L-glutamate Source: Ensembl
Negative regulation of axon extension Source: BHF-UCL
Negative regulation of branching morphogenesis of a nerve Source: Ensembl
Negative regulation of collateral sprouting Source: BHF-UCL
Negative regulation of dendrite development Source: BHF-UCL
Negative regulation of dendrite extension Source: Ensembl
Negative regulation of neuron projection development Source: BHF-UCL
Negative regulation of neuron remodeling Source: Ensembl
Negative regulation of protein homooligomerization Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of collateral sprouting Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron projection development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein sumoylation Source: UniProtKB
Regulation of dendrite development Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Cytoplasm; Nucleus; Chromosome. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity).
Isoform 1: Nucleus matrix. Colocalizes with BCL6 in nuclear paraspeckles.
Isoform 2: Cytoplasm; Nucleus. Predominantly localized in the nucleus in nuclear paraspeckles.
Isoform 3: Cytoplasm; Nucleus. Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles.
Involvement in disease
Chromosomal aberrations involving BCL11A are associated with B-cell malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and overexpression.
Intellectual developmental disorder with persistence of fetal hemoglobin (IDPFH): An autosomal dominant disorder characterized by delayed psychomotor development, intellectual disability, variable dysmorphic features, including microcephaly, downslanting palpebral fissures, strabismus, and external ear abnormalities, and asymptomatic persistence of fetal hemoglobin.
PTM
Sumoylated with SUMO1.
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For research use only. Not intended for any clinical use.

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