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Mouse Anti-B4GALT4 Recombinant Antibody (CBYY-0096) (CBMAB-0096-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0096
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 40-322 of human B4GALT4 produced in E.coli.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Beta-1,3-Galactosyltransferase 4
Introduction
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
8702
UniProt ID
O60513
Alternative Names
Beta-1,4-Galactosyltransferase 4; UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 4; UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 4; UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 4; Beta-1,4-GalTase 4; Beta4Gal-T4;
Function
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Biological Process
Carbohydrate metabolic process Source: InterPro
Glycosylation Source: GO_Central
Keratan sulfate biosynthetic process Source: Reactome
Membrane lipid metabolic process Source: ProtInc
Protein glycosylation Source: UniProtKB-UniPathway
Cellular Location
Golgi stack membrane. Trans cisternae of Golgi stack.
Topology
Cytoplasmic: 1-12 aa
Helical: 13-38 aa
Lumenal: 39-344 aa
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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