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Mouse Anti-B3GNT2 Recombinant Antibody (CBYY-1886) (CBMAB-2235-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-1886
Antibody Isotype
IgG2a
Application
WB, FC, IF

Basic Information

Immunogen
Full length human recombinant protein of human B3GNT2 produced in HEK293T cell.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:100
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Introduction
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
10678
UniProt ID
Q9NY97
Alternative Names
UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2; UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 1; Beta3Gn-T1; Beta3Gn-T2; B3GNT1; BGnT-2; UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 7; N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 2; UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 7; Beta-1,3-N-Acetylglucosaminyltransferase BGnT-1; Beta-1,3-N-Acetylglucosaminyltransferase BGnT-2; Beta-1,3-N-Acetylglucosaminyltransferase 1; Beta-1,3-N-Acetylglucosaminyltransferase 2; Beta-1,3-Galactosyltransferase 7; Beta-1,3-GalTase 7; Beta-1,3-Gn-T1; Beta-1,3-Gn-T2;
Function
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646).
Probably constitutes the main polylactosamine synthase.
Biological Process
Axon guidance Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Keratan sulfate biosynthetic process Source: Reactome
O-glycan processing Source: Reactome
Poly-N-acetyllactosamine biosynthetic process Source: UniProtKB
Protein glycosylation Source: GO_Central
Sensory perception of smell Source: Ensembl
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-7 aa
Helical: 8-28 aa
Lumenal: 29-397 aa
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For research use only. Not intended for any clinical use.

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