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Mouse Anti-B3GNT2 Recombinant Antibody (CBYY-0084) (CBMAB-0084-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0084
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human beta-1,3-N-acetylglucosaminyltransferase 2/B3GNT2 Lys29-Cys397.
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Introduction
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
10678
UniProt ID
Q9NY97
Alternative Names
UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2; UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 1; Beta3Gn-T1; Beta3Gn-T2; B3GNT1; BGnT-2; UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,3-Galactosyltransferase 7; N-Acetyllactosaminide Beta-1,3-N-Acetylglucosaminyltransferase 2; UDP-Gal:Beta-GlcNAc Beta-1,3-Galactosyltransferase 7; Beta-1,3-N-Acetylglucosaminyltransferase BGnT-1; Beta-1,3-N-Acetylglucosaminyltransferase BGnT-2; Beta-1,3-N-Acetylglucosaminyltransferase 1; Beta-1,3-N-Acetylglucosaminyltransferase 2; Beta-1,3-Galactosyltransferase 7; Beta-1,3-GalTase 7; Beta-1,3-Gn-T1; Beta-1,3-Gn-T2;
Function
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646).
Probably constitutes the main polylactosamine synthase.
Biological Process
Axon guidance Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Keratan sulfate biosynthetic process Source: Reactome
O-glycan processing Source: Reactome
Poly-N-acetyllactosamine biosynthetic process Source: UniProtKB
Protein glycosylation Source: GO_Central
Sensory perception of smell Source: Ensembl
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-7 aa
Helical: 8-28 aa
Lumenal: 29-397 aa
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For research use only. Not intended for any clinical use.

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