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Mouse Anti-ASH1L Recombinant Antibody (4G12) (CBMAB-A3772-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ASH1L (NP_060959. 1, 2859-2967 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ash1 (absent, small, or homeotic)-like (Drosophila)
Introduction
ASH1L is a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.
Entrez Gene ID
55870
UniProt ID
Q9NR48
Alternative Names
ASH1 Like Histone Lysine Methyltransferase; Absent Small And Homeotic Disks Protein 1 Homolog; Lysine N-Methyltransferase 2H; ASH1-Like Protein; EC 2.1.1.43; KMT2H; Ash1 (Absent, Small, Or Homeotic)-Like (Drosophila); Probable Histone-Lysine N-Methyltrans
Function
Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497).
Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity).
The physiological significance of the H3K9me1 activity is unclear (By similarity).
Biological Process
Decidualization Source: Ensembl
Flagellated sperm motility Source: Ensembl
Histone H3-K36 dimethylation Source: HGNC
Negative regulation of acute inflammatory response Source: Ensembl
Negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
Negative regulation of MAPK cascade Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Post-embryonic development Source: Ensembl
Single fertilization Source: Ensembl
Skeletal system development Source: Ensembl
Tarsal gland development Source: Ensembl
Uterine gland development Source: Ensembl
Uterus morphogenesis Source: Ensembl
Cellular Location
Nucleus; Tight junction; Chromosome. The relevance of tight junction localization is however unclear.
Involvement in disease
Mental retardation, autosomal dominant 52 (MRD52): A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Methylated at Gln-1220 by N6AMT1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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