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Rat Anti-ARTN Recombinant Antibody (BA0379) (CBMAB-0101CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
BA0379
Antibody Isotype
IgG2a
Application
IHC, WB

Basic Information

Immunogen
E. coli-derived recombinant mouse Artemin Ala112-Gly224.
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml
IHC3-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Artemin
Introduction
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
Entrez Gene ID
Human9048
Mouse11876
Rat362572
UniProt ID
HumanQ5T4W7
MouseQ9Z0L2
RatQ6AYE8
Alternative Names
Artemin; Neublastin; Neurotrophic Factor' ENOVIN; EVN; NBN
Function
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
Biological Process
Axon guidance Source: Reactome
Induction of positive chemotaxis Source: Ensembl
Lymphocyte migration into lymphoid organs Source: Ensembl
MAPK cascade Source: Reactome
Neuroblast proliferation Source: ProtInc
Peripheral nervous system development Source: GO_Central
Peyer's patch morphogenesis Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
More Infomation

Gupta, A., Chiavaccini, L., Minnema, L. M., Chiu, K. W., Knazovicky, D., Hash, J. A., ... & Lascelles, B. D. X. (2021). Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain. Scientific reports, 11(1), 1-11.

Huang, H. M., Huang, C. C., Poon, L. Y. C., & Chang, Y. C. (2021). Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis. Frontiers in molecular neuroscience, 14, 56.

Zhu, S., Li, Y., Bennett, S., Chen, J., Weng, I. Z., Huang, L., ... & Xu, J. (2020). The role of glial cell line‐derived neurotrophic factor family member artemin in neurological disorders and cancers. Cell proliferation, 53(7), e12860.

Feng, S., Sim, H. W., Bucur, R., Aggarwal, R., Abreu, P., Ray, M., ... & Chen, E. X. (2020). Preoperative serum artemin (ARTN) as a predictive biomarker of recurrence following curative resection for hepatocellular carcinoma (HCC).

Odesina, P. A. O. (2019). Determination of the Relationship Between Artemin Expression Levels in Blood and Breast Cancer (Doctoral dissertation, Auckland University of Technology).

Ilieva, M., Nielsen, J., Korshunova, I., Gotfryd, K., Bock, E., Pankratova, S., & Michel, T. M. (2019). Artemin and an artemin-derived peptide, artefin, induce neuronal survival, and differentiation through RET and NCAM. Frontiers in molecular neuroscience, 12, 47.

Edamitsu, T., Taguchi, K., Kobayashi, E. H., Okuyama, R., & Yamamoto, M. (2019). Aryl hydrocarbon receptor directly regulates artemin gene expression. Molecular and cellular biology, 39(20), e00190-19.

Hezam, K., Jiang, J., Sun, F., Zhang, X., & Zhang, J. (2018). Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the Neurosciences, 29(1), 93-98.

Matsumoto, A., Murota, H., Terao, M., & Katayama, I. (2018). Attenuated activation of homeostatic glucocorticoid in keratinocytes induces alloknesis via aberrant artemin production. Journal of Investigative Dermatology, 138(7), 1491-1500.

Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., ... & Yamamoto, M. (2017). The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature immunology, 18(1), 64-73.

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For research use only. Not intended for any clinical use.

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