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Mouse Anti-ARID3A Recombinant Antibody (ARIDE9C11) (CBMAB-D0029-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
ARIDE9C11
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to a region near the N-terminus of DRIL1 of human origin.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ARID3A
Introduction
ARID3A is a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. ARID3A was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis.
Entrez Gene ID
1820
UniProt ID
Q99856
Alternative Names
AT-Rich Interaction Domain 3A; AT Rich Interactive Domain 3A (BRIGHT-Like); B-Cell Regulator Of IgH Transcription; ARID Domain-Containing Protein 3A; Dead Ringer-Like Protein 1; E2F-Binding Protein 1; BRIGHT; E2FBP1; DRIL1;
Function
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Cytoplasm; Nucleus. Shuttles between nucleus and cytoplasm.
More Infomation

Tang, J., Yang, L., Li, Y., Ning, X., Chaulagain, A., Wang, T., & Wang, D. (2021). ARID3A promotes the development of colorectal cancer by upregulating AURKA. Carcinogenesis, 42(4), 578-586.

Garton, J. W., Shankar, M., Guthridge, J., James, J. A., & Webb, C. (2021). ARID3a Defines a Novel Subset of Naïve B Cells in SLE Patients.

Arman, K., Saadat, K. A., Igci, Y. Z., Bozgeyik, E., Ikeda, M. A., Cakmak, E. A., & Arslan, A. (2020). Long noncoding RNA ERICD interacts with ARID3A via E2F1 and regulates migration and proliferation of osteosarcoma cells. Cell Biology International, 44(11), 2263-2274.

Ratliff, M. L., Shankar, M., Guthridge, J. M., James, J. A., & Webb, C. F. (2020). TLR engagement induces ARID3a in human blood hematopoietic progenitors and modulates IFNα production. Cellular immunology, 357, 104201.

Saadat, K. A., Bozgeyik, E., Arman, K., Bozgeyik, I., & Ikeda, M. A. (2020). ARID3A-mediated modulation of TP73 and TP73-AS1 in osteosarcoma cells. Gene Reports, 20, 100683.

Yoon, G., Park, J. Y., Kim, H. J., Choi, G. S., Kim, J. G., Kang, B. W., ... & Seo, A. N. (2019). ARID3A positivity correlated with favorable prognosis in patients with residual rectal cancer after Neoadjuvant chemoradiotherapy. Anticancer research, 39(6), 2845-2853.

Garton, J., Barron, M. D., Ratliff, M. L., & Webb, C. F. (2019). New Frontiers: ARID3a in SLE. Cells, 8(10), 1136.

Garton, J. W., Chapman, B., Shankar, M., Rose, K., & Webb, C. (2019). The DNA-binding protein ARID3a is Required for Human Erythrocyte Lineage Differentiation using the K562 Model Cell Line.

Garton, J. W., Pelikan, R., Ratliff, M., James, J. A., Gaffney, P., & Webb, C. F. (2018). Genes associated with ARID3a expression in B Lymphocytes from Systemic Lupus Erythematosus patients.

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For research use only. Not intended for any clinical use.

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