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Mouse Anti-APBA3 Recombinant Antibody (H-6) (CBMAB-X0001-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
H-6
Antibody Isotype
IgM, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 74-99 within an internal region of X11γ of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amyloid Beta Precursor Protein Binding Family A Member 3
Introduction
APBA3 is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. It is a member of the X11 protein family, which is believed to be involved in signal transduction processes.APBA3 may modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta and also may enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Entrez Gene ID
Human9546
Mouse57267
Rat83611
UniProt ID
HumanO96018
MouseO88888
RatO70248
Alternative Names
X11L2; mint3; MGC:15815
Function
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Biological Process
Chemical synaptic transmission Source: GO_Central
In utero embryonic development Source: Ensembl
Negative regulation of catalytic activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of gene expression Source: Ensembl
Cellular Location
Perinuclear region
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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