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Mouse Anti-APBA3 Recombinant Antibody (CBFYM-0863) (CBMAB-M1010-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYM-0863
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-206 mapping at the N-terminus of X11γ of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 63-185

Target

Full Name
Amyloid Beta Precursor Protein Binding Family A Member 3
Introduction
The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
Entrez Gene ID
Human9546
Mouse57267
UniProt ID
HumanO96018
MouseO88888
Alternative Names
Amyloid Beta Precursor Protein Binding Family A Member 3; Neuronal Munc18-1-Interacting Protein 3; Neuron-Specific X11L2 Protein; Adapter Protein X11gamma; Mint-3; Mint3; X11L2; Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member 3 (X11-Like 2)
Function
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Biological Process
Chemical synaptic transmission Source: GO_Central
In utero embryonic development Source: Ensembl
Negative regulation of catalytic activity Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of gene expression Source: Ensembl
Cellular Location
Perinuclear region
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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