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Mouse Anti-ANTXR1 Recombinant Antibody (CBYJT-1041) (CBMAB-T0046-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-1041
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, IHC-P

Basic Information

Immunogen
Amino acids 481-497 of TEM8 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 28-320

Target

Full Name
Anthrax Toxin Receptor 1
Introduction
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. ANTXR1 has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to ANTXR1 mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Entrez Gene ID
84168
UniProt ID
Q9H6X2
Alternative Names
Anthrax Toxin Receptor 1; Tumor Endothelial Marker 8; TEM8; ATR; Tumor Endothelial Marker 8 Precursor; Anthrax Toxin Receptor; 2310008J16Rik; 2810405N18Rik; GAPO
Function
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
Biological Process
Actin cytoskeleton reorganization Source: UniProtKB
Blood vessel development Source: Ensembl
Negative regulation of extracellular matrix assembly Source: Ensembl
Positive regulation of metallopeptidase activity Source: Ensembl
Reproductive process Source: Ensembl
Substrate adhesion-dependent cell spreading Source: UniProtKB
Toxin transport Source: GO_Central
Cellular Location
Cell membrane; Lamellipodium membrane; Filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
Involvement in disease
Hemangioma, capillary infantile (HCI): A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.
GAPO syndrome (GAPOS): An autosomal recessive disease characterized by growth retardation, alopecia, failure of tooth eruption, and progressive optic atrophy in some patients.
Topology
Extracellular: 33-321 aa
Helical: 322-342 aa
Cytoplasmic: 343-564 aa
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For research use only. Not intended for any clinical use.

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