Rat Anti-ANGPTL7 Recombinant Antibody (CBYC-A601) (CBMAB-A2740-YC)

Name: Rat Anti-ANGPTL7 Recombinant Antibody (CBYC-A601)
SKU: CBMAB-A2740-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

CBYC-A601

Antibody Isotype

IgG2b

Application

IHC, WB

Basic Information

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant mouse Angiopoietin-like Protein 7/ANGPTL7 Gln22-Pro337.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	0.5 µg/ml
IHC	8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Angiopoietin Like 7

Introduction

ANGPTL7 (Angiopoietin Like 7) is a protein coding gene. And an important paralog of this gene is ANGPT4.

Entrez Gene ID

654812

UniProt ID

Q8R1Q3

Alternative Names

Angiopoietin Like 7; Cornea-Derived Transcript 6 Protein; Angiopoietin-Like Protein 7; CDT6; Angiopoietin-Like Factor (CDT6); Angiopoietin-Related Protein 7;

Function

Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036).

Biological Process

Angiogenesis Source: GO_Central
Negative regulation of vasculature development involved in avascular cornea development in camera-type eye Source: UniProtKB
Regulation of extracellular matrix organization Source: UniProtKB
Response to oxidative stress Source: ProtInc

Cellular Location

Secreted

More Infomation

References

Xia, X., Ren, Z., Yan, L., Zheng, X., Yang, H., Kang, M., ... & Yang, J. (2020). Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants. BioMed Research International, 2020.

Li, J., Liang, T., Wang, Y., Gan, Y., Kou, Z., Zhang, Y., ... & Xie, D. (2020). Angiopoietin-like protein 7 mediates TNF-α-induced adhesion and oxidative stress in human umbilical vein epithelial cell. General physiology and biophysics, 39(3), 285-292.

Zhang, C., He, X., Zhao, J., Cao, Y., Liu, J., Liang, W., ... & Liu, C. (2020). Angiopoietin-like protein 7 and short-term mortality in acute heart failure. Cardiorenal medicine, 10(2), 116-124.

Zhao, Y., Liu, K., Yin, D., & Lin, Z. (2019). Angiopoietin-like 7 contributes to angiotensin II-induced proliferation, inflammation and apoptosis in vascular smooth muscle cells. Pharmacology, 104(5-6), 226-234.

Lu, X., Lu, J., Zhang, L., & Xu, Y. (2019). Effect of ANGPTL7 on Proliferation and Differentiation of MC3T3-E1 Cells. Medical science monitor: international medical journal of experimental and clinical research, 25, 9524.

Abu-Farha, M., Cherian, P., Al-Khairi, I., Madhu, D., Tiss, A., Warsam, S., ... & Abubaker, J. (2017). Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise. PloS one, 12(3), e0173024.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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